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A new class of self-designing clinical trials

A new class of self-designing clinical trials

Studies in Health Technology and Informatics 77: 310-314

A class of self-designing clinical trials is considered which according to an effective but simple, finite learning algorithm consists of automatically adaptively planned weighted group sequential trials with a decision about rejection of the null-hypothesis at each step, but the full level-alpha-test at the end of the study preserved.

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Accession: 045079449

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PMID: 11187563

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