+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A new combined DTP-HBV-Hib vaccine--strategy for incorporation of Hib vaccination into childhood immunisation programmes



A new combined DTP-HBV-Hib vaccine--strategy for incorporation of Hib vaccination into childhood immunisation programmes



South African Medical Journal 91(10): 864-869



To evaluate the immunogenicity and reactogenicity of a pentavalent vaccine prepared by extemporaneously mixing diphtheria-tetanus pertussis-hepatitis B vaccine (DTP-HBV) and lyophilised Haemophilus influenzae type B (Hib)-tetanus conjugate vaccines in the same syringe, compared with the same vaccines given as separate, concomitant administrations. Open, randomised comparative study. Durban, South Africa. A total of 120 healthy male and female infants were enrolled in the trial and randomised into two groups; group 1 received the combined administration (DTP-HBV-Hib), and group 2 received separate administrations of DTP-HBV and Hib vaccines. Vaccines were given as a three-dose primary vaccination course at 2, 4 and 6 months [corrected] of age. Antibody levels were measured using standard techniques and local and general solicited symptoms were recorded using diary cards. All subjects had seroprotective titres against diphtheria and tetanus; and antipolyribose-ribitol phosphate (PRP) titres > or = 0.15 microgram/ml 1 month after the final dose. A vaccine response (defined as post-vaccination titres > or = 15 ELISA (EL).U/ml in initially seronegative subjects; and as post-vaccination titres > or = pre-vaccination titres in initially seropositive subjects) against the pertussis component was seen in 83% and 85% of subjects in the groups receiving combined and separate administration. No differences were seen in any of the geometric mean titres (GMTs) between the two administrations either 2 months after the second dose or 1 month after the final dose. There was no observed increase in reactogenicity in the group receiving the mixed administration. The results demonstrate that combined DTP-HBV-Hib vaccine is well tolerated and immunogenic.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 045079562

Download citation: RISBibTeXText

PMID: 11732460


Related references

Should hepatitis B vaccination be introduced into childhood immunisation programmes in northern Europe?. Lancet. Infectious Diseases 7(6): 410-419, 2007

Integration of hepatitis B vaccination into national immunisation programmes. Delivering vaccine to infants at risk is complex. Bmj 315(7100): 121, 1997

Integration of hepatitis B vaccination into national immunisation programmes. Alternative strategies must be considered before universal vaccination is adopted. Bmj 315(7100): 121-122, 1997

Vaccine safety versus vaccine efficacy in mass immunisation programmes. Lancet 338(8778): 1309-1312, 1991

Efficiency of the incorporation of the hepatitis A vaccine as a combined A+B vaccine to the hepatitis B vaccination programme of preadolescents in schools. Vaccine 23(17-18): 2185-2189, 2005

Economic evaluation of a combined DTPa, hepatitis B, polio, Hib vaccine. Potential impact of the introduction of Infanrix-Hexa in the French childhood immunisation schedule. European Journal of Health Economics 5(2): 143-149, 2004

Oral immunisation against pox. 3 relationship between vaccine dose and vaccination success in drinking water vaccination against fowl pox with the attenuated strain HP-1. Zentralblatt fur Veterinarmedizin: Reihe B: 19 (8) 609-614, 1972

The national childhood immunisation programmes in Singapore. Singapore Medical Journal 26(3): 225-242, 1985

Immunisation Information Systems - useful tools for monitoring vaccination programmes in EU/EEA countries, 2016. Euro Surveillance 22(17):, 2017

A call for the introduction of gender-neutral HPV vaccination to national immunisation programmes in Africa. Lancet. Global Health 7(1): E20-E21, 2019

Introduction of pneumococcal vaccine to standard immunisation programmes in Europe: what are we waiting for?. European Journal of Pediatrics 161(Suppl. 2): S125-S126, 2002

Universal childhood immunisation with pneumococcal vaccine and meningococcal serogroup C vaccine introduced in Germany. Euro Surveillance 11(9): E060907.4, 2006

Vaccination programmes out of pace with vaccine development: a call for national vaccination registers. Acta Paediatrica 88(8): 800-802, 1999

Efficacy of vaccination against Newcastle disease with different vaccination programmes and different types of vaccine. Dt. tierarztl. Wschr, Veterinar-Labor, Industriestrasse 6, Cuxhaven 77: 393-398, 1970

Analysis of varicella vaccine breakthrough rates: Implications for the effectiveness of immunisation programmes. Vaccine 18(25): 2775-2778, 15 June, 2000