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A new complex of palladium-thiourea and carbon tetrabromide catalyzed carbonylative annulation of o-hydroxylarylacetylenes: efficient new synthetic technology for the synthesis of 2,3-disubstituted benzo[b]furans



A new complex of palladium-thiourea and carbon tetrabromide catalyzed carbonylative annulation of o-hydroxylarylacetylenes: efficient new synthetic technology for the synthesis of 2,3-disubstituted benzo[b]furans



Organic Letters 2(3): 297-299



[reaction: see text] A highly effective cocatalysis system (PdI2-thiourea and CBr4) was developed for carbonylative cyclization of both electron-rich and electron-deficient o-hydroxylarylacetylenes to the corresponding methyl benzo[b]furan-3-carboxylates.

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Accession: 045079585

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PMID: 10814306

DOI: 10.1021/ol991327b


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