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A new concept for substitutes in vascular surgery

A new concept for substitutes in vascular surgery

Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 115: 1256-1259

In a tissue engineering approach to develop vascular grafts without disadvantages such as early thrombosis, neointimal hyperplasia, the inability to grow, aneurysm formation, as well as life-long anticoagulation, decellularized matrix tubes which were obtained by enzymatic cell extraction from a porcine aorta were seeded with human endothelial cells in vitro. This procedure led to completely biological vascular grafts with good handling qualities and sufficient burst strength, presumably suitable for implantation in the arterial circuit.

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Accession: 045079626

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PMID: 9931852

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