+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers



A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers



Journal of Physiology and Pharmacology 50(2): 169-181



The healing of experimental gastric ulcers induced in rats is consistently delayed upon chronic treatment with indomethacin. This study was designed to examine both the fate of such delayed ulcers and the effects of various antiulcer drugs on the delayed ulcers. Four-week treatment with indomethacin significantly delayed the healing of acetic acid ulcers. Such ulcers remained unhealed for up to 12 weeks after cessation of indomethacin treatment, and were thus designated as "unhealed ulcers". Two-week administration of sucralfate, cimetidine or omeprazole significantly reduced the ulcerated area, yet aluminum hydroxide had little or no effect. Four-week administration of sucralfate also extensively reduced the size of the "unhealed ulcers", yet aluminum hydroxide, cimetidine and omeprazole had an insignificant effect on "unhealed ulcers". In the 2 and 4 week sucralfate-treated group, the pH of the gastric contents was 4.0 vs. 1.7 and 4.5 vs. 2.1 in the control groups, respectively. Gastric acid secretion was extensively inhibited by cimetidine and omeprazole. It is concluded that prolonged indomethacin treatment results in the development of "unhealed ulcers" and that only sucralfate has a beneficial effect on such ulcers, irrespective of the length of the treatment.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 045084439

Download citation: RISBibTeXText

PMID: 10424715


Related references

Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. Journal of Physiology and Pharmacology 54(3): 349-360, 2003

Characterization of unhealed acetic acid ulcers induced by chronic treatment with indomethacin. Japanese Journal of Pharmacology 71(SUPPL 1): 203P, 1996

Effects of sucralfate, omeprazole and rhEGF on unhealed gastric ulcers induced in rats by repeated treatment with indomethacin. Gastroenterology 116(4 PART 2): A112, 1999

Effect of indomethacin on healed acetic acid-induced gastric ulcers in rats. Japanese Journal of Pharmacology 61(SUPPL 1): 106P, 1993

Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin. Gastroenterology 96(2 Pt 1): 393-402, 1989

Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. Gastroenterology 100(5 Pt 1): 1259-1265, 1991

Effect of prednisolone or indomethacin on the various stage of healing of acetic acid-induced gastric ulcers in rats. Gastroenterology 104(4 SUPPL ): A163, 1993

Effect of concurrent administration of indomethacin and prednisolone on the healing of acetic acid-induced gastric ulcers in rats. Gastroenterology 104(4 SUPPL ): A163, 1993

Defensive factors of experimental ulcers 1. changes in tissue components of gastric mucosa and stroma during the healing process of acetic acid ulcers in rats and effects of anti ulcer drugs. Japanese Journal of Pharmacology 31(SUPPL): 172P, 1981

Immunohistochemical and morphological changes in the healing stage of human gastric ulcers and acetic acid-induced ulcers in rats with age. Biomedical Research 7(2): 165-174, 1996

Relationship between vascular endothelial growth factor and angiogenesis in spontaneous and indomethacin-delayed healing of acetic acid-induced gastric ulcers in rats. Journal of Physiology and Pharmacology 49(4): 515-527, 1999

Effects of aging on the ulcer-healing activities of cimetidine and omeprazole in acetic acid-induced gastric ulcers in rats. Japanese Journal of Pharmacology 79(SUPPL 1): 294P, 1998

Effects of the new anti-ulcer agent 12-sulfodehydroabietic acid monosodium salt on healing of acetic acid-induced gastric ulcers in rats. Arzneimittel-Forschung 41(5): 546-548, 1991

Influence of indomethacin on gastric mucosal blood flow in the rat with acetic acid induced gastric ulcers. Gastroenterology 98(5 PART 2): A99, 1990

Influence of KU-1257 on the recurrence and relapse of acetic acid-induced chronic gastric ulcers in rats. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 107(2): 67-78, 1996