+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A patient with isolated prolongation of aPTT without hemorrhagic diathesis anamnesis: severe, hereditary factor XII deficiency

A patient with isolated prolongation of aPTT without hemorrhagic diathesis anamnesis: severe, hereditary factor XII deficiency

Therapeutische Umschau. Revue Therapeutique 56(9): 509-512

By virtue of a severely prolonged aPTT with a normal thromboplastin time (prothrombin time) and a normal thrombin time, severe FXII deficiency has been diagnosed in a woman without a bleeding diathesis or a history of thromboembolic complications. A deficiency of a factor of the contact activation system (FXII, prekallikrein, high molecular weight kininogen) is usually diagnosed during routine coagulation tests demonstrating a prolonged aPTT. The severe and partial deficiency of FXII, of prekallikrein or high molecular weight kininogen is not associated with a bleeding tendency. In contrast, severely factor XI deficient subjects may suffer from a mild hemorrhagic diathesis, whereas FVIII deficiency (hemophilia A, autoimmune "hemophilia", von Willebrand disease) and FIX deficiency (hemophilia B) are associated with a bleeding tendency of varying severity, depending on the clotting activity of FVIII or FIX, respectively. An isolated prolongation of the aPTT due to a lupus anticoagulant, however, is frequently associated with arterial and/or venous thrombosis. Therefore, in case of a prolongation of the aPTT, its cause has to be determined.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 045090670

Download citation: RISBibTeXText

PMID: 10517121

Related references

Isolated increased aPTT with anamnestic hemorrhagic diathesis--severe FXI deficiency. Therapeutische Umschau. Revue Therapeutique 56(9): 502-504, 1999

Applying a direct aPTT ratio (PlatelinLS/ActinFS) permits to identify rapidly and reliably a bleeding-related factor deficiency or a lupus anticoagulant sequential to an isolated prolongation of aPTT in paediatric pre-operative screening. European Journal of Haematology 96(6): 578-585, 2016

Prevalent factor XII deficiency in cancer patients with isolated aPTT prolongation. Blood Research 50(2): 114-117, 2015

Factor 13 deficiency with severe hemorrhagic diathesis. Blood 28(1): 34-39, 1966

Isolated congenital factor V deficiency as cause of hemorrhagic diathesis. Wiener Zeitschrift für Innere Medizin und ihre Grenzgebiete 40(1): 10-16, 1959

Hemorrhagic diathesis due to a familial, isolated Factor-XI(PTA)-deficiency. Die Medizinische Welt 24(17): 701-703, 1973

Acquired Hemorrhagic Diathesis Caused by Isolated Factor X Deficiency. Nederlands Tijdschrift Voor Geneeskunde 109: 852-854, 1965

Isolated factor V deficiency in a patient with elevated PT and aPTT during routine pre-operative laboratory screening. Stem Cell Investigation 1: 4, 2014

Prekallikrein (Fletcher Factor) Deficiency and Prolongation of APTT Reaction. Medizinische Klinik 98(10): 587-590, 2003

Hereditary autosomal hemorrhagic diathesis with antihemophilic globulin deficiency & prolonged bleeding time. Nordisk Medicin 59(1): 12-16, 1958

Hemorrhagic diathesis due to factor VII deficiency. A.M.A. Archives of Internal Medicine 99(2): 280-284, 1957

Factor 5 deficiency in hemorrhagic diathesis. Jour Amer Med Assoc 148(6): 462-463, 1952

Celiac sprue presenting as severe hemorrhagic diathesis due to vitamin K deficiency. Israel Medical Association Journal 6(12): 781-783, 2004

Hemorrhagic diathesis due to factor VII deficiency (hypoproconvertinemia). Nederlands Tijdschrift Voor Geneeskunde 98(42): 2987-3001, 1954

Hemorrhagic diathesis caused by deficiency of factor VII. Probl Gematol I Perelivaniya Krovi : 163-172, 1962