+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A study on the dosage of carboplatin for bronchial arterial infusion in combination with radiation therapy



A study on the dosage of carboplatin for bronchial arterial infusion in combination with radiation therapy



Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(15): 2603-2607



Radiation therapy holds an important position as one of the multidisciplinary methods of treating lung cancer (non-small cell carcinoma). As a result of the development of platinum preparations such as cisplatin (CDDP) and wide use of digital subtraction angiography (DSA), selective bronchial arterial infusion (BAI) therapy made possible more effective use of anti-lung cancer drugs. The use of radiation therapy in combination with BAI is now recommended as a more effective method. Meanwhile carboplatin (CBDCA) has recently been developed as a second generation platinum preparation with less side effects, and is being used for BAI, too. However, the maximum tolerated dose (MTD) of CB DCA for BAI to be used in combination with radiation therapy is not known yet. We, therefore, carried out a phase-study to determine MTD of CBD CA for combination with radiation therapy. The results show that the MTD of CBDCA is 400 mg/m2, and that clinically recommendable infusion limit is 350 mg/m2. In an angiographic study performed at the same time, a plural number of tumor affected blood vessels were found in 81.3% of the patients with lung cancer. Therefore, infusion of a drug for such patients should be carefully applied.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 045118756

Download citation: RISBibTeXText

PMID: 7979420


Related references

A combination therapy of continuous superselective intraarterial carboplatin infusion and radiation therapy for locally advanced head and neck carcinoma: A Phase I study. Cancer 89(10): 2099-2105, November 10, 2000

Evaluation of a method for calculating carboplatin dosage in DeVIC ± R therapy (combination therapy of dexamethasone, etoposide, ifosfamide and carboplatin with or without rituximab) as a salvage therapy in patients with relapsed or refractory non-Hodgkin lymphoma. Cancer ChemoTherapy and Pharmacology 78(2): 305-312, 2017

A case report--Efficacy of combination therapy to unresectable advanced gall bladder carcinoma--palliative operation, hepatic arterial infusion therapy, and radiation therapy. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 31(11): 1903-1905, 2004

Carboplatin dosage formulae can generate inaccurate predictions of carboplatin exposure in carboplatin/paclitaxel combination regimens. Clinical Drug Investigation. 15(4): 327-335, Il, 1998

A case report of hepatocellular carcinoma (Vp4)--an attempt to reduce residual tumor thrombus using combination therapy (hepatic arterial infusion, hepatic arterial embolization and radiation). Gan to Kagaku Ryoho. Cancer and ChemoTherapy 32(11): 1812-1814, 2005

Bronchial arterial infusion with carboplatin for the treatment of primary lung cancer patients with impaired renal function. Journal of Saitama Medical School 20(3): 175-181, 1993

Clinicopathological study on combination therapy consisting of arterial infusion of lipiodol-dissolved SMANCS and transcatheter arterial embolization for hepatocellular carcinoma. Cancer ChemoTherapy and Pharmacology 31 Suppl: S7-12, 1992

Radiation in combination with intra-arterial infusion therapy with dacarbazine for metastatic malignant melanoma localized to a lower extremity. Cancer Treatment Reports 70(8): 1015-1017, 1986

Long term results of bronchial arterial infusion with chemotherapeutic agents plus radiation therapy in the teratment of locally advanced non small cell lung cancer. Chinese Journal of Cancer Research 11(1): 66-69, 1999

A clinical evaluation of combination therapy with radiation, MCNU, carboplatin and IFN-beta or with radiation, MCNU, carboplatin, etoposide and IFN-beta for malignant gliomas. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 25(13): 2055-2060, 1998

Therapy for advanced hepatocellular carcinoma with vessel invasion with combination of hepatic arterial infusion chemotherapy, interferon therapy, and conformal radiation focusing on vessel tumor thrombus. Hepatology 36(4 Part 2): 689A, 2002

Treatment results of continuous intra-arterial CBDCA infusion chemotherapy in combination with radiation therapy for locally advanced tongue cancer. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 105(6): 714-719, 2008

A phase I study of UFT/leucovorin, carboplatin, and paclitaxel in combination with external beam radiation therapy for advanced esophageal carcinoma. International Journal of Radiation Oncology, Biology, Physics 70(4): 1066-1072, 2007

Therapy of maxillary cancer, type T3, with special reference to combination of 3 methods including preoperative localized intra-arterial injectiona and massive dosage radiation in a short period. Nihon Jibiinkoka Gakkai Kaiho 74(2): 400, 1971

Chemoradiation therapy using radiotherapy, systemic chemotherapy with 5-fluorouracil and nedaplatin, and intra-arterial infusion using carboplatin for locally advanced head and neck cancer - Phase II study. Oral Oncology 43(10): 1014-1020, 2007