Ability of bone marrow cells to generate active forms of oxygen in C57Bl/6 and BALB/C mice and mutagenic effects of dioxidine

Guseva, N.V.; Durnev, A.D.; Seredenin, S.B.

Voprosy Meditsinskoi Khimii 41(4): 25-28

1995


ISSN/ISBN: 0042-8809
PMID: 8571581
Accession: 045138176

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Abstract
Phorbol-myristate acetate- and opsonized zymosan-induced statistically significant differences were shown in the intensity of chemiluminescence occurring in the bone marrow cell suspension. The bone marrow cells from male BALB/c mice showed the most pronounced response to stimulation in the two cases. After 5-day administration of dioxidine (300 mg/kg), the number of the injured metaphases in the bone marrow from the examined animals was 43.6 +/- 2.2 and 23.8 +/- 1.9% in BALB/c and C57B1/6 mice, respectively, which provides evidence for marked strain-specific differences in the cytogenetic effect of this proxidative mutagen. The findings indicated that there was a relationship between the capacity of bone marrow cells of producing APA and the severity of cytogenetic lesions in these cells.