+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Alpha 1-adrenoceptor antagonist decreases alpha 2-adrenoceptor antagonist-induced high voltage spindle suppression in adult and aged rats

Alpha 1-adrenoceptor antagonist decreases alpha 2-adrenoceptor antagonist-induced high voltage spindle suppression in adult and aged rats

European Journal of Pharmacology 235(2-3): 317-320

The present experiments were undertaken to study whether blockade of alpha 1-adrenoceptors would prevent the high-voltage spindle suppressing effect of atipamezole, an alpha 2-adrenoceptor antagonist. In adult rats, an alpha 1-adrenoceptor antagonist, prazosin, increased dose dependently the high voltage spindles in saline and atipamezole-pretreated rats. In addition, in aged rats prazosin blocked the high-voltage spindle suppressing action of atipamezole. Prazosin produced a smaller increase in high-voltage spindle values in aged than in adult rats. According to the present results, alpha 2-adrenoceptor antagonists may suppress high-voltage spindles indirectly by activating alpha 1-adrenoceptors in young and aged rats.

(PDF emailed within 1 workday: $29.90)

Accession: 045203789

Download citation: RISBibTeXText

PMID: 8099554

Related references

Effects of medetomidine, an alpha-2 adrenoceptor agonist, and atipamezole, an alpha-2 antagonist, on spatial memory performance in adult and aged rats. Behavioral and Neural Biology 58(2): 113-119, 1992

Continuous alpha 2-adrenoceptor blockade by atipamezole decreases neocortical high-voltage spindle activity in rats. European Journal of Pharmacology 221(2-3): 351-357, 1992

Stimulation of insulin release and cAMP levels in isolated rat islets by the imidazoline alpha 2-adrenoceptor antagonist midaglizole: comparison with the action of the alpha 2-adrenoceptor antagonist yohimbine. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 105(3): 137-144, 1995

Tissue selectivity of in vivo alpha-1-adrenoceptor binding of KMD-3213, a novel alpha-1A-adrenoceptor antagonist, in rats. Neurourology & Urodynamics 16(5): 493-495, 1997

Characterization of in vivo alpha-1-adrenoceptor binding of JTH-601 a novel alpha-1L-adrenoceptor antagonist, in rats. Neurourology & Urodynamics 16(5): 489-490, 1997

RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective alpha 1A-adrenoceptor antagonist, displays low affinity for functional alpha 1-adrenoceptors in human prostate: implications for adrenoceptor classification. Molecular Pharmacology 49(2): 209-215, 1996

Effect of labetalol an alpha adrenoceptor antagonist and beta adrenoceptor antagonist on gastric acid and gastrin secretion in man. British Journal Of Clinical Pharmacology: 744-746, 1982

Effects of PN 200-110, a new calcium antagonist, on alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction elicited by selective alpha-adrenoceptor agonists and catecholamines in the pithed rat. Archives Internationales de Pharmacodynamie et de Therapie 278(1): 72-86, 1985

Celiprolol, a potent cardioselective beta 1-adrenoceptor antagonist with mild alpha 2-adrenoceptor antagonist properties. Journal of Hypertension. Supplement 3(3): S195-S197, 1985

Comparison of once and twice daily oral dosing schedules of bevantolol, a new beta-adrenoceptor antagonist with alpha-adrenoceptor partial antagonist activity in patients with angina of effort. International Journal of Cardiology 25(2): 185-192, 1989

Characterization of the adrenoceptor antagonistic and antihypertensive activity of oral amosulalol, a combined alpha- and beta-adrenoceptor antagonist, in hypertensive rats. Journal of Cardiovascular Pharmacology 24(5): 794-802, 1994

The prejunctional alpha 2 adrenoceptor antagonist activity of cirazoline a new alpha 1 adrenoceptor agonist on field stimulated guinea pig ileum. Journal of Pharmacy & Pharmacology 35(SUPPL): 91P, 1983

Postsynaptic alpha-adrenoceptor reserve and the shift of the concentration-response curves to the right, as caused by the irreversible alpha-adrenoceptor antagonist phenoxybenzamine. British Journal of Pharmacology 92(3): 505-512, 1987

Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. Bioorganic and Medicinal Chemistry Letters 8(11): 1353-1358, 1999

Study on midaglizole an alpha 2 adrenoceptor antagonist further evidence for the lack of central alpha 2 adrenoceptor blocking activities. Asia Pacific Journal of Pharmacology 5(4): 317-320, 1990