+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

An unusual autopsy case of corticobasal degeneration--with special reference to clinicopathological differentiation from progressive supranuclear palsy and slowly progressive aphasia

An unusual autopsy case of corticobasal degeneration--with special reference to clinicopathological differentiation from progressive supranuclear palsy and slowly progressive aphasia

No to Shinkei 48(6): 559-565

We report an unusual autopsy case of corticobasal degeneration. The patient was male who was 67 years old at the time of his death. He developed clumsiness of his right hand at age 65. Neurological examination at age 66 revealed supranuclear ophthalmoplegia of upward gaze and parkinsonism. Progressive supranuclear palsy was suspected. The patient's clinical course was rapidly progressive. Dementia developed nine months after the onset of the disease, and the patient manifested apallic syndrome at 21 months and died of pneumonia at about 25 months. At autopsy the brain weighed 1370g. Macroscopic examination revealed prominent atrophy of the anterior and parietal lobes, particularly of the pars opercularis in the left inferior frontal gyrus, and there was marked depigmentation of the substantia nigra. Histological examination showed neuronal loss, glial proliferation, spongy state, and ballooned neurons in the frontal and parietal lobes. Neuronal loss with glial proliferation was conspicuous in the striatum, pallidum, thalamus, and substantia nigra. There was slight neuronal loss in the dentate nucleus and locus ceruleus. Staining by Gallyas-Braak method revealed massive appearance of argyrophilic threads. This case is important in terms of the clinical differentiation from progressive supranuclear palsy, and is also interesting in regard to the pathological correlation with slowly progressive aphasia.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 045238727

Download citation: RISBibTeXText

PMID: 8703559

Related references

Progressive supranuclear palsy presenting with primary progressive aphasia--clinicopathological report of an autopsy case. Acta Neuropathologica 105(6): 610-614, 2003

Pick Complex: an integrative approach to frontotemporal dementia: primary progressive aphasia, corticobasal degeneration, and progressive supranuclear palsy. Neurologist 9(6): 311-317, 2003

Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. JAMA Neurology 73(6): 733-742, 2016

Corticobasal degeneration: an autopsy case clinically diagnosed as progressive supranuclear palsy. Clinical Neuropathology 19(4): 192-199, 2000

An autopsy case of corticobasal degeneration without prominent cortical pathology--an imitator of progressive supranuclear palsy. Rinsho Shinkeigaku 40(4): 372-377, 2000

Progressive supranuclear palsy and corticobasal degeneration: Diagnostic challenges and clinicopathological considerations. Revue Neurologique 172(8-9): 488-502, 2016

Apraxia of speech and nonfluent aphasia: a new clinical marker for corticobasal degeneration and progressive supranuclear palsy. Current Opinion in Neurology 21(6): 688-692, 2008

Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. Journal of Neurology 246(Suppl. 2): II/6-II/15, 1999

Neuropsychological findings in clinically atypical autopsy confirmed corticobasal degeneration and progressive supranuclear palsy. Parkinsonism and Related Disorders 14(4): 376-378, 2008

Pathologic changes of progressive supranuclear palsy, corticobasal degeneration, and multiple system atrophy - Prototype and clinicopathological diversity. Journal of Neurology 253(Suppl. 3): 41-46, 2006

Corticobasal degeneration and progressive supranuclear palsy--differentiation by somatosensory-evoked potentials. No to Shinkei 48(3): 253-257, 1996

Similarities and differences among progressive among progressive supranuclear palsy, corticobasal degeneration and Pick's disease. Neuropathology 16(4): 262-268, 1996

Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: Differentiation from progressive supranuclear palsy. Acta Neuropathologica 90(1): 37-43, 1995

Progressive supranuclear palsy and corticobasal ganglionic degeneration: differentiation by clinical features and neuroimaging techniques. Journal of Neural Transmission. Supplementum 42: 79-90, 1994

A case with clinical features of progressive supranuclear palsy with apraxia--corticobasal degeneration?. Rinsho Shinkeigaku 34(11): 1168-1170, 1994