+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Anti-diarrhoeal and gastro-intestinal potentials of the aqueous extract of Phyllanthus amarus (Euphorbiaceae)

Anti-diarrhoeal and gastro-intestinal potentials of the aqueous extract of Phyllanthus amarus (Euphorbiaceae)

African Journal of Medicine and Medical Sciences 29(2): 119-122

The anti-diarrhoeal and gastro-intestinal protective potentials of aqueous extract of leaves of Phyllanthus amarus were investigated in mice. Graded doses of the aqueous extract (100-800 mg/kg) administered orally produced a dose-related inhibition of gut meal travel distance in normal mice. The highest intestinal transit inhibition of 31.65% was obtained with 400 mg/kg. In castor oil induced diarrhoea in mice, P. amarus extract (400 mg/kg) delayed the onset of diarrhoea, reduced frequency of defecation and reduced gut meal travel distance significantly resulting in intestinal transit inhibition of 79.94% compared to 86.92% produced by morphine (100 mg/kg). In addition, the activities of some intestinal mucosa enzymes (maltase, sucrase, lactase and alkaline phosphatase) in mice pretreated with extract before castor oil were not as severely depressed as those in the control (castor oil treated mice). Phytochemical screening revealed the presence of many secondary metabolites. The results are discussed with a view to establishing the basis of the use of this plant in traditional medicine for treatment of diarrhoea and other gastrointestinal disorders.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 045269224

Download citation: RISBibTeXText

PMID: 11379441

Related references

Anti-inflammatory and antinociceptive activities of bufalin in rodents. Mediators of Inflammation 2014: 171839, 2014

Hypotensive effect of aqueous extract of Averrhoa carambola L. (Oxalidaceae) in rats: an in vivo and in vitro approach. Journal of Ethnopharmacology 133(2): 353-357, 2011

The anti-HIV actions of 7- and 10-substituted camptothecins. Molecules 15(1): 138-148, 2010

The quantification of dynamic FET PET imaging and correlation with the clinical outcome in patients with glioblastoma. Physics in Medicine and Biology 54(18): 5525-5539, 2009

The evaluation of the healing rate of subtalar arthrodeses, part 2: the effect of low-intensity ultrasound stimulation. Foot and Ankle International 29(10): 970-977, 2008

Antimicrobial efficacy of UV radiation on Escherichia coli O157:H7 (EDL 933) in fruit juices of different absorptivities. Journal of Food Protection 68(1): 49-58, 2005

Analgesic activity of aqueous extract of Stereospermum kunthianum (Cham, Sandrine Petit) stem bark. Acta Poloniae Pharmaceutica 66(1): 83-88, 2009

Antioxidant potential of all-trans retinoic acid (ATRA) and enhanced activity of liposome encapsulated ATRA against inflammation and tumor-directed angiogenesis. Immunopharmacology and Immunotoxicology 35(1): 164-173, 2013

Some churches to visit in Quebec. From the poetry of the space to the reason for existence. Teoros, Revue de Recherche en Tourisme 24(2): 17-25, 2005

Protective effect of ischemic preconditioning against hepatic ischemic injury during the course of liver resection in a rat model. 2007

Safety evaluation of an enzymatic fish protein hydrolysate: 10 month feeding study and reproduction performance in rats. Journal of food science: 42 (2) 407-409, 1977

Aqueous extract of Mosla chinensis inhibits mast cell-mediated allergic inflammation. American Journal of Chinese Medicine 40(6): 1257-1270, 2012

Hypocholesterolemic effects of phenolic extracts and purified hydroxytyrosol recovered from olive mill wastewater in rats fed a cholesterol-rich diet. Journal of Agricultural and Food Chemistry 55(3): 624-631, 2007

The effect of Penshibao on seed germination and seedlings of peanut under different temperatures. Journal of South China Agricultural University 23(1): 5-8, 2002

Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation. European Journal of Pharmacology 510(3): 223-228, 2005