+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antibody responses to respiratory coronavirus infections of cattle during shipping fever pathogenesis



Antibody responses to respiratory coronavirus infections of cattle during shipping fever pathogenesis



Archives of Virology 145(11): 2335-2349



Antibody responses against respiratory bovine coronavirus (RBCV) infections were monitored in cattle from the onset of a naturally occurring severe shipping fever (SF) epizootic to complete recovery of affected cattle or fatal outcomes. The infection with RBCV was detected in nasal secretions of 86 cattle, and 81 of them developed acute respiratory tract disease, including fatal pneumonia. Cattle nasally shedding RBCV at the beginning of the epizootic experienced characteristic primary immune responses with specific antibodies for hemagglutinin-esterase (HE) and spike (S) glycoproteins. Virus shedding in nasal secretions of the majority of the cattle ceased between days 7 and 14 with the appearance of HE- and S-specific antibodies. Nasal samples and lung tissues from 9 of the 10 fatal cases had high titers of RBCV, but these cattle had only IgM responses to RBCV infections. Cattle remaining negative in RBCV isolation tests entered this epizootic with antibodies against HE and S. Protection against respiratory tract disease was apparently associated with high level of opsonic and virus-neutralizing IgG2. The HE and S glycoproteins were recognized earliest by the bovine immune system while the N protein induced antibody responses during the later stage of initial infection and the early stage of reinfection. The membrane (M) glycoprotein was the least immunogenic of the major viral structural proteins.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 045273556

Download citation: RISBibTeXText

PMID: 11205121


Related references

Antibody responses of cattle with respiratory coronavirus infections during pathogenesis of shipping fever pneumonia are lower with antigens of enteric strains than with those of a respiratory strain. Clinical and Diagnostic Laboratory Immunology 9(5): 1010-1013, 2002

Infectivity-neutralizing and hemagglutinin-inhibiting antibody responses to respiratory coronavirus infections of cattle in pathogenesis of shipping fever pneumonia. Clinical and Diagnostic Laboratory Immunology 8(2): 357-362, 2001

Isolation of respiratory bovine coronavirus, other cytocidal viruses, and Pasteurella spp from cattle involved in two natural outbreaks of shipping fever. Journal of the American Veterinary Medical Association 216(10): 1599-1604, 2000

Coronavirus and Pasteurella infections in bovine shipping fever pneumonia and Evans' criteria for causation. Journal of Clinical Microbiology 38(9): 3291-3298, 2000

The pathogenesis of shipping fever in cattle. Proceedingsannual convention American Association of Bovine Practitioners: 3th) 103-112, 1980

Coronavirus isolation from nasal swab samples in cattle with signs of respiratory tract disease after shipping. Journal of the American Veterinary Medical Association 208(9): 1452-1455, 1996

Studies on shipping fever of cattle. 3. Comparison of Pasteurella spp. isolated from shipping fever and other infectious processes. Indian Veterinary Journal 43(1): 1-8, 1966

Studies on shipping fever of cattle III. Comparison of Pasteurella spp. isolated from shipping fever and other infectious processes. Indian vet. J 43: 1-8, 1966

Respiratory coronaviruses and Pasteurella haemolytica in shipping fever pneumonia of cattle. Abstracts of the General Meeting of the American Society for Microbiology 100: 687, 2000

Comments on management of respiratory diseases of dairy cattle shipping fever. Journal of the American Veterinary Medical Association 152(6 Part 2): 932-933, 1968

Epidemiologic factors and isotype-specific antibody responses in serum and mucosal secretions of dairy calves with bovine coronavirus respiratory tract and enteric tract infections. American Journal of Veterinary Research 52(6): 845-851, 1991

Studies on shipping fever of cattle. II. Prevalence of Pasteurella species in nasal secretions from normal calves and calves with shipping fever. American Journal of Veterinary Research 22: 470-472, 1961

Studies on shipping fever of cattle. II. Prevalence of Pasteurella spp. in nasal secretions from normal calves and calves with shipping fever. Amer Jour Vet Res 22(88): 470-472, 1961

Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus. Journal of Virology 81(24): 13681-13693, 2007

A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory disease of cattle. Canadian Journal of Comparative Medicine 46(3): 225-263, 1982