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Antimycotic agents in oral candidosis: an overview: 2. Treatment of oral candidosis



Antimycotic agents in oral candidosis: an overview: 2. Treatment of oral candidosis



Dental Update 27(4): 165



As both humans and fungi are eukaryotic organisms, antifungal agents affect their cellular metabolism. Thus, a relatively few antifungals with minimal toxicity and side-effects are available compared with a plethora of antibacterials. These agents currently prescribed in dentistry belong to two major groups, the polyenes (nystatin and amphotericin B) and the azoles (imidazoles and triazoles). A newly recognized phenomenon known as the post-antifungal effect implies that antifungals, even at sub-therapeutic concentrations, may suppress the virulent attributes of yeasts, especially intra-orally where topical drug levels fluctuate dramatically during dosing intervals.

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Accession: 045278414

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PMID: 11218451


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