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Application of decoy strategy

Application of decoy strategy

Nihon Rinsho. Japanese Journal of Clinical Medicine 54(9): 2583-2590

ISSN/ISBN: 0047-1852

PMID: 8890596

Recently, transfection of cis-element double stranded (ds) oligodeoxynucleotides (ODN) (= decoy) as a new powerful tool in a new class of anti-gene strategy for gene therapy and the study of transcriptional regulation has been reported. Transfection of ds ODN corresponding to cis sequence will result in the attenuation of authentic cis-trans interaction, leading to the removal of trans-factors from the endogenous cis-element with subsequent modulation of gene expression. Recent studies provide evidence of on in vivo application of this novel molecular approach as a therapeutic strategy against cardiovascular disease, and tool for the study of gene regulation in vivo.

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