+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Are late-onset schizophrenia spectrum disorders neurodegenerative conditions? Annual rates of change on two dementia measures



Are late-onset schizophrenia spectrum disorders neurodegenerative conditions? Annual rates of change on two dementia measures



Journal of Neuropsychiatry and Clinical Neurosciences 15(1): 45-52



Some investigators assert that emergence of schizophrenia spectrum disorders in mid- to late life (LOSD, i.e., onset after age 45) reflects neurodegenerative processes. The authors examined 1- and 2-year changes among 37 outpatients with LOSDs on the Mini-Mental State Examination (MMSE) and Mattis Dementia Rating Scale, compared with 69 patients having earlier-onset schizophrenia spectrum disorders (EOSD), 67 having Alzheimer's disease (AD) with psychosis, 72 having AD with baseline MMSE scores >/=24, and 56 normal comparison subjects (NCs). Cognitive changes among LOSD patients were similar to those in EOSD patients and NCs, whereas the AD groups had greater declines. Results support viewing LOSDs as static encephalopathies.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 045297660

Download citation: RISBibTeXText

PMID: 12556570

DOI: 10.1176/jnp.15.1.45


Related references

Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. European Archives of Psychiatry and Clinical Neuroscience 264(4): 317-331, 2014

Comparative study of clinical and neuropsychological characteristics between early-, late and very-late-onset schizophrenia-spectrum disorders. American Journal of Geriatric Psychiatry 23(8): 852-862, 2015

Parental schizophrenia spectrum disorders in childhood-onset and adult-onset schizophrenia. American Journal of Psychiatry 160(3): 490-495, 2003

Childhood onset schizophrenia and early onset schizophrenia spectrum disorders. Child and Adolescent Psychiatric Clinics of North America 22(4): 539-555, 2013

Neurodegenerative aspects in vulnerability to schizophrenia spectrum disorders. Neurotoxicity Research 26(4): 400-413, 2014

Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study. American Journal of Psychiatry 165(11): 1420-1431, 2008

Is late-onset schizophrenia related to neurodegenerative processes? A review of literature. L'Encephale 35(4): 386-393, 2009

Development of the CHARIOT Research Register for the Prevention of Alzheimer's Dementia and Other Late Onset Neurodegenerative Diseases. Plos one 10(11): E0141806, 2015

Association of adoptive child's thought disorders and schizophrenia spectrum disorders with their genetic liability for schizophrenia spectrum disorders, season of birth and parental Communication Deviance. Psychiatry Research 226(2-3): 434-440, 2015

Age at onset mixture analysis and systematic comparison in schizophrenia spectrum disorders: Is the onset heterogeneity dependent on heterogeneous diagnosis?. Schizophrenia Research 164(1-3): 83-91, 2015

Annual incidence rate of schizophrenia and schizophrenia spectrum disorders in a longitudinal population-based cohort study. Social Psychiatry and Psychiatric Epidemiology 48(9): 1357-1365, 2013

Long-term follow-up and phenomenologic differences distinguish among late-onset schizophrenia, late-life depression, and progressive dementia. American Journal of Geriatric Psychiatry 11(6): 589-594, 2003

Bipolar disorder, schizophrenia, and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disorders. Journal of Neural Transmission 111(7): 891-902, 2004

Distinctive characteristics of early-onset and late-onset neuromyelitis optica spectrum disorders. International Journal of Neuroscience 127(4): 334-338, 2017

Do patients with late-onset schizophrenia develop dementia?. Society for Neuroscience Abstracts 21(1-3): 745, 1995