+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Advances in Pathophysiology of Calcific Aortic Valve Disease Propose Novel Molecular Therapeutic Targets

Advances in Pathophysiology of Calcific Aortic Valve Disease Propose Novel Molecular Therapeutic Targets

Frontiers in Cardiovascular Medicine 5: 21

Calcific Aortic Valve Disease (CAVD) is the most common heart valve disease and its incidence is expected to rise with aging population. No medical treatment so far has shown slowing progression of CAVD progression. Surgery remains to this day the only way to treat it. Effective drug therapy can only be achieved through a better insight into the pathogenic mechanisms underlying CAVD. The cellular and molecular events leading to leaflets calcification are complex. Upon endothelium cell damage, oxidized LDLs trigger a proinflammatory response disrupting healthy cross-talk between valve endothelial and interstitial cells. Therefore, valve interstitial cells transform into osteoblasts and mineralize the leaflets. Studies have investigated signaling pathways driving and connecting lipid metabolism, inflammation and osteogenesis. This review draws a summary of the recent advances and discusses their exploitation as promising therapeutic targets to treat CAVD and reduce valve replacement.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 045335690

Download citation: RISBibTeXText

PMID: 29594151

DOI: 10.3389/fcvm.2018.00021

Related references

Calcific Aortic Valve Disease: Molecular Mechanisms and Therapeutic Approaches. European Cardiology 10(2): 108-112, 2015

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation 124(16): 1783-1791, 2012

Novel pharmacological targets for calcific aortic valve disease: Prevention and treatments. Pharmacological Research 136: 74-82, 2018

Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arteriosclerosis Thrombosis and Vascular Biology 34(11): 2387-2393, 2014

Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease. Cardiovascular Research 76(1): 19-28, 2007

New therapeutic targets for calcific aortic valve stenosis: the lipoprotein(a)-lipoprotein-associated phospholipase A2-oxidized phospholipid axis. Journal of the American College of Cardiology 63(5): 478-480, 2014

Calcific aortic valve disease: imaging studies and therapeutic interventions. Journal of Investigative Medicine 55(6): 292-298, 2007

Molecular imaging of calcific aortic valve disease. Journal of Nuclear Cardiology 25(4): 1148-1155, 2018

Molecular and cellular aspects of calcific aortic valve disease. Circulation Research 113(2): 198-208, 2013

Molecular biology of calcific aortic valve disease: towards new pharmacological therapies. Expert Review of Cardiovascular Therapy 12(7): 851-862, 2014

Calcific bicuspid aortic valve disease in a patient with Cornelia de Lange syndrome: linking altered Notch signaling to aortic valve disease. Cardiovascular Pathology 15(3): 165-167, 2006

Calcific Disease of the Aortic Valve. A Comprehensive, Analytic Survey of Calcific Sclerosis. American Journal of Clinical Pathology 18(4): 336.1-337, 1948

Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease. Journal of Nuclear Medicine 56(6): 933-938, 2015

Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks. Journal of Cardiovascular Translational Research 9(2): 102-118, 2016

Computational assessment of bicuspid aortic valve wall-shear stress: implications for calcific aortic valve disease. Biomechanics and Modeling in Mechanobiology 11(7): 1085-1096, 2012