Section 46
Chapter 45,358

Behaviour of IgG antibody avidity for the antigen and of IgA antibody in active cytomegalovirus, Epstein-Barr virus, herpes simplex virus and human herpes virus 6 infections. Adaptation of a commercial test

Gutiérrez, J.; Rodríguez, M.; Maroto, M.C.; Piédrola, G.; Peirón, J.

Journal of Infection 35(1): 25-30


ISSN/ISBN: 0163-4453
PMID: 9279720
DOI: 10.1016/s0163-4453(97)90881-1
Accession: 045357935

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The clinical value of specific IgA and IgG antibody avidity to herpes simplex virus, cytomegalovirus, Epstein-Barr virus and human herpes virus 6 for the detection of active disease and primary infection, respectively, was evaluated. The IgG avidity test, with a break point of 55%, for the detection of primary infection, and of the IgA test for the detection of disease, were associated with a sensitivity of 97% and 64%, respectively; specificity of 100% and 82%; a positive predictive value of 100% and 76%; and a negative predictive value of 96% and 72%, respectively.

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