+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Cancer genetics of TSC2 gene mutant(Eker) rat model

Cancer genetics of TSC2 gene mutant(Eker) rat model

Nihon Rinsho. Japanese Journal of Clinical Medicine 58(6): 1255-1261

Cancer is a heritable disorder of somatic cells. Environment and heredity both operate in the origin of human cancer. Hereditary cancers have been important in the understanding of carcinogenesis, and have pointed to the first tumor suppressor genes. Such a hereditary cancer was described in the rat by Reidar Eker in 1954. The Eker rat model of hereditary renal carcinoma is an example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. We identified a germline mutation in the rat homologous to the human tuberous sclerosis gene (TSC2) as the predisposing Eker gene. The Eker rat provides a valuable experimental model for understanding the mechanisms of disease, and the development of the therapeutic treatments.

(PDF emailed within 1 workday: $29.90)

Accession: 045433018

Download citation: RISBibTeXText

PMID: 10879050

Related references

TSC2 gene mutant (Eker) rat model of a Mendelian dominantly inherited cancer. Progress in Experimental Tumor Research 35: 95-108, 1999

Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Archives of Biochemistry and Biophysics 572: 36-39, 2015

Presence of a modifier gene(s) affecting early renal carcinogenesis in the Tsc2 mutant (Eker) rat model. International Journal of Oncology 24(1): 75-80, 2003

Identification of cDNAs induced by the tumor suppressor Tsc2 gene using a conditional expression system in Tsc2 mutant (Eker) rat renal carcinoma cells. Biochemical and Biophysical Research Communications 247(3): 728-733, 1998

Mapping and determination of the cDNA sequence of the Erc gene preferentially expressed in renal cell carcinoma in the Tsc2 gene mutant (Eker) rat model. Biochemical and Biophysical Research Communications 275(1): 134-140, 2000

Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Biochemical and Biophysical Research Communications 241(1): 24-30, 1998

A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nature Genetics 9(1): 70-74, 1995

Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry. Virchows Archiv 434(4): 341-350, 1999

Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats. International Journal of Oncology 18(1): 147-149, 2000

Specific induction of hepatocellular adenomas by transplacental administration of ENU in the tsc2 gene mutant (Eker) rat. International Journal of Oncology 13(5): 957-961, 1998

Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model. Cancer Science 94(1): 22-25, 2003

The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene. Biochemical and Biophysical Research Communications 203(2): 1302-1308, 1994

Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene. Proceedings of the National Academy of Sciences of the United States of America 94(8): 3990-3993, 1997

Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model. Cancer Research 56(3): 429-433, 1996

Transgenic Rescue From Embryonic Lethality and Renal Carcinogenesis in the Eker Rat Model by Introduction of a Wild-Type Tsc2 Gene. Journal of Urology 159(2): 619-620, 1998