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Catalytic asymmetric dihydroxylation using phenoxyethoxymethyl-polystyrene (PEM) -based novel microencapsulated osmium tetroxide (PEM-MC OsO4)

Kobayashi, S.; Ishida, T.; Akiyama, R.

Organic Letters 3(17): 2649-2652

2001


ISSN/ISBN: 1523-7060
PMID: 11506600
DOI: 10.1021/ol0161965
Accession: 045455721

[reaction: see text]. A phenoxyethoxymethyl-polystyrene (PEM)-based novel polymer-supported osmium catalyst has been developed. The catalyst was readily prepared from PEM polymer based on a microencapsulation technique, and asymmetric dihydroxylation of olefins has been successfully performed using (DHQD)2PHAL as a chiral ligand and K3Fe(CN)6 as a cooxidant in H2O/acetone. The catalyst was recovered quantitatively by simple filtration and reused without loss of activity several times.

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