Home
  >  
Section 46
  >  
Chapter 45,481

Changes of amino acids release in rat's hippocampus during kainic acid induced epilepsy and acupuncture

Liu, J.; Cheng, J.

Zhen Ci Yan Jiu 20(3): 50-54

1995

ISSN/ISBN: 1000-0607
PMID: 8758830
Accession: 045480771
Download citation:  
Text
  |  
BibTeX
  |  
RIS
Changes of amino acids release in rat's hippocampus were studied by using push-pull perfusion and high performance liquid chromatography (HPLC) with fluorometric detection techniques during kainic acid (KA) induced epilepsy and acupuncture. The results indicated that the levels of glutamate, aspartate, glycine and GABA were statistically increased in hippocampus 40min after administration of KA. After EA treatment, there was marked elevation in the extracellular level of taurine. It's shown that the inhibitory effect of EA on epilepsy may be related to the increase of inhibitory amino acids's release in hippocampus.

PDF emailed within 1 workday: $29.90




Related References

Geula, C.; Slevin, J.T. 1986: Effect of entorhinal kindling on potassium or kainic acid stimulated release of amino acids in rat hippocampus Society for Neuroscience Abstracts 12(1): 344
Fukunishi, I.; Murakami, T.; Negi, T.; Hosokawa, K. 1990: The release of zinc and amino acids into the hippocampus by intracranial perfusion of kainic acid studies using brain microdialysis and timm staining Neurosciences 16(4): 613-622
Stein-Behrens, B.A.; Elliott, E.M.; Miller, C.A.; Schilling, J.W.; Newcombe, R.; Sapolsky, R.M. 1992: Glucocorticoids exacerbate kainic acid-induced extracellular accumulation of excitatory amino acids in the rat hippocampus Journal of Neurochemistry 58(5): 1730-1735
Connick, J.H.; Stone, T.W. 1986: The effect of kainic acid quinolinic acid and beta kainic acid on the release of endogenous amino acids from rat brain slices Biochemical Pharmacology 35(20): 3631-3636
Virgili, M.; Poli, A.; Contestabile, A.; Migani, P.; Barnabei, O. 1986: Synaptosomal release of newly-synthetized or recently accumulated amino acids. Differential effects of kainic acid on naturally occurring excitatory amino acids and on [d-(3)H]aspartate Neurochemistry International 9(1): 29-33
Virgili, M.; Poli, A.; Contestabile, A.; Migani, P.; Barnabei, O. 1986: Synaptosomal release of newly synthetized or recently accumulated amino acids differential effects of kainic acid on naturally occurring excitatory amino acids and on tritiated d aspartate Neurochemistry International 9(1): 29-34
Kim, S-Tae.; Doo, A-Reum.; Kim, S-Nam.; Kim, S-Yi.; Kim, Y.Young.; Kim, J-Hyun.; Lee, H.; Yin, C.Shik.; Park, H-Joon. 2012: Acupuncture suppresses kainic acid-induced neuronal death and inflammatory events in mouse hippocampus Journal of Physiological Sciences: Jps 62(5): 377-383
Bae, C-Hwan.; Kim, D-Soo.; Jun, Y.Lee.; Kwon, S.; Park, H-Joon.; Hahm, D-Hyun.; Lee, H.; Kim, S-Tae. 2013: Proteomic analysis of the effect of acupuncture on the suppression of kainic Acid-induced neuronal destruction in mouse hippocampus Evidence-Based Complementary and Alternative Medicine: Ecam 2013: 436315
Connick, J.H.; Stone, T.W. 1986: The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices Biochemical Pharmacology 35(20): 3631-3635
Qiao, X.; Werkman, T.R.; Gorter, J.A.; Wadman, W.J.; van Vliet, E.A. 2013: Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy Epilepsy Research 106(1-2): 17-28
Wang Buer, Cheng Jieshi 1996: Course of nitric oxide synthase mRNA alterations during kainic acid-induced epilepsy in rat hippocampus Acta Academiae Medicinae Shanghai 23(5): 373-374
Li, X.; Yang, C.; Shi, Y.; Guan, L.; Li, H.; Li, S.; Li, Y.; Zhang, Y.; Lin, J. 2021: Abnormal neuronal damage and inflammation in the hippocampus of kainic acid-induced epilepsy mice Cell Biochemistry and Function 39(6): 791-801
Tokumaru, J.; Ueda, Y.; Doi, T.; Mitsuyama, Y. 2000: Collapse of extracellular glutamate regulation in the hippocampus of kainic acid-induced epilepsy model Neuroscience Research Suppl (24): S65
Lu, C.W.; Lin, T.Y.; Wang, S.J. 2020: 11-Keto-β-Boswellic Acid Attenuates Glutamate Release and Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus Planta Medica 86(6): 434-441
Angelatou, F.; Ekonomou, A.; Sperk, G.; Mitsacos, A.; Kostopoulos, G. 1998: Decrease of A1 adenosine receptors in hippocampus of a rat temporal lobe epilepsy model induced by kainic acid Society for Neuroscience Abstracts 24(1-2): 1209
Tsunashima, K.; Schwarzer, C.; Kirchmair, E.; Sieghart, W.; Sperk, G. 1997: GABA(A) receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy Neuroscience 80(4): 1019-1032
Lasoń, W.; Przewłocka, B.; Przewłocki, R. 1990: The release of alpha-neoendorphin from rat hippocampus following kainic acid-induced seizures Progress in Clinical and Biological Research 328: 257-260
Liao, E-Tzu.; Tang, N-Ying.; Lin, Y-Wen.; Liang Hsieh, C. 2017: Long-term electrical stimulation at ear and electro-acupuncture at ST36-ST37 attenuated COX-2 in the CA1 of hippocampus in kainic acid-induced epileptic seizure rats Scientific Reports 7(1): 472
Shikhanov, N.P.; Ivanov, N.M.; Khovriakov, A.V.; Casperson, K.; McKhann, G.M.; Krugliakov, P.P.; Sosunov, A.A. 2004: Neuronal damage in the hippocampus of inbred mouse strains in the models of epilepsy induced by kainic acid and pilocarpine Morfologiia 125(3): 63-67
Schwarzer, C.; Tsunashima, K.; Wanzenböck, C.; Fuchs, K.; Sieghart, W.; Sperk, G. 1997: GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy Neuroscience 80(4): 1001-1017