+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Changing perspectives of H2 antagonists for stress ulcer prophylaxis

Changing perspectives of H2 antagonists for stress ulcer prophylaxis

Critical Care Nursing Clinics of North America 5(2): 325-331

Bleeding from stress-related mucosal damage is a feared complication in critically ill patients. For the past 20 years antacids, and then H2 antagonists, have been the mainstays for protecting patients from stress bleeding. Recent evidence, however, questions the need for such therapy for most intensive care unit patients. Furthermore, increasing the intragastric pH may predispose patients to the development of nosocomial pneumonias, which carries a greater risk of mortality than does bleeding from stress ulcers. In patients who require gastric protection, sucralfate, which has no effect on gastric pH, is the preferred choice.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 045482364

Download citation: RISBibTeXText

PMID: 8104424

Related references

Changing perspectives of stress gastritis prophylaxis. Annals of PharmacoTherapy 28(9): 1073-1085, 1994

Stress ulcer prophylaxis: are PPIs truly superior compared to H2 receptor antagonists?. Zeitschrift für Gastroenterologie 54(10): 1168-1169, 2016

Cost-effectiveness analysis: stress ulcer bleeding prophylaxis with proton pump inhibitors, H2 receptor antagonists. Value in Health 16(1): 14-22, 2013

Sucralfate versus antacids or h 2 antagonists for stress ulcer prophylaxis a meta analysis of efficacy and pneumonia rate. Critical Care Medicine 19(7): 942-949, 1991

Cost-Effectiveness of Histamine 2 Receptor Antagonists Versus Proton Pump Inhibitors for Stress Ulcer Prophylaxis in Critically Ill Patients. PharmacoTherapy 37(1): 43-53, 2017

Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis. Critical Care Medicine 41(3): 693-705, 2013

The efficacy and safety of proton pump inhibitors vs histamine-2 receptor antagonists for stress ulcer bleeding prophylaxis among critical care patients: a meta-analysis. Critical Care Medicine 38(4): 1197-1205, 2010

Effect of histamine-2-receptor antagonists versus sucralfate on stress ulcer prophylaxis in mechanically ventilated patients: a meta-analysis of 10 randomized controlled trials. Critical Care 14(5): R194, 2010

Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis. World Journal of Critical Care Medicine 5(1): 57-64, 2016

Nosocomial pneumonia during stress ulcer prophylaxis? - risk of nosocomial pneumonia is increased during stress ulcer prophylaxis. Deutsche Medizinische Wochenschrift 138(47): 2398, 2013

Evaluation of an alternative posaconazole prophylaxis regimen in haematological malignancy patients receiving concomitant stress ulcer prophylaxis. International Journal of Antimicrobial Agents 40(6): 557-561, 2012

Changing perspectives in diabetic foot ulcer management. International Journal of Lower Extremity Wounds 2(1): 4, 2003

Pneumonia and stress ulceration in severely injured patients. A prospective evaluation of the effects of stress ulcer prophylaxis. Archives of Surgery 128(2): 185-91; Discussion 191-2, 1993

Stress gastrointestinal hemorrhage and nosocomial pneumonia in mechanically-ventilated children receiving stress ulcer prophylaxis. Clinical Research 40(3): 695A, 1992