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Characterization of the S protein of enterotropic murine coronavirus strain-Y



Characterization of the S protein of enterotropic murine coronavirus strain-Y



Advances in Experimental Medicine and Biology 380: 23-28



The pathogenesis of enterotropic murine coronavirus strain MHV-Y differs extensively from that of prototypic respiratory strains of murine coronaviruses. The S protein of MHV-Y was characterized as a first step towards identifying viral determinants of enterotropism. Immunoblots of MHV-Y virions using anti-S protein specific antiserum revealed that the MHV-Y S protein was inefficiently cleaved. The MHV-Y S gene was cloned and sequenced. It encodes a protein predicted to be 1361 amino acids long. The presence of several amino acids changes within and surrounding the predicted cleavage site of the MHV-Y S protein may contribute to its inefficient cleavage.

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Accession: 045493520

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PMID: 8830485


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