+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Characterization of urinary metabolites of a new benzofuroquinoline derivative, 3,9-bis(N,N-dimethylcarbamoyloxy)-5 H-benzofuro[3,2-c]-quinoline-6-one (KCA-098), in dogs



Characterization of urinary metabolites of a new benzofuroquinoline derivative, 3,9-bis(N,N-dimethylcarbamoyloxy)-5 H-benzofuro[3,2-c]-quinoline-6-one (KCA-098), in dogs



Die Pharmazie 54(9): 672-677



The metabolism of 3,9-bis(N,N-dimethylcarbamoyloxy)-5 H-benzofuro[3,2-c]-quinoline-6-one (KCA-098), a new inhibitor of bone resorption and stimulator of bone formation, was examined after oral administration to dogs. Nine metabolites and the unchanged KCA-098 were isolated by extraction and HPLC from dog urine. The structures of these metabolites were characterized by LC/MS or LC/MS/MS, and/or were confirmed by comparison with corresponding authentic standards. The presumed main metabolic pathways were hydrolysis, hydroxylation, and N-demethylation of the N,N-dimethyl-carbamate ester group.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 045495344

Download citation: RISBibTeXText

PMID: 10522271


Related references

Characterization of urinary metabolites of a new benzofuroquinoline derivative, 3,9-bis -5 H-benzofuro -quinoline-6-one , in dogs. Pharmazie 54(9): 672-677, 1999

Polymorphism of 3,9-bis-(N,N-dimethylcarbamoyloxy)-5H-benzofuro[3,2- c]quinoline-6-one(KCA-098), a new benzofuroquinoline derivative. Yakugaku Zasshi 115(12): 978-984, 1995

Inclusion complex of 3,9-bis(N,N-dimethylcarbamoyloxy)-5H-benzofuro(3,2-c)quinoline-6-one (KCA-098) with heptakis(2,6-di-O-methyl)-beta-cyclodextrin: Interaction and dissolution properties. Biological and Pharmaceutical Bulletin 23(9): 1264-1269, 2000

Inclusion complex of 3,9-bis(N,N-dimethylcarbamoyloxy)-5H-benzofuro[3,2-c]quinoline-6-one (KCA-098) with heptakis(2,6-di-O-methyl)-beta-cyclodextrin: interaction and dissolution properties. Chemical and Pharmaceutical Bulletin 48(9): 1264-1269, 2000

The synthesis of benzofuro quinolines part 1 some benzofuro 2 3 b quinoline and benzofuro 3 2 c quinoline derivatives. Journal of Heterocyclic Chemistry 16(3): 487-492, 1979

Direct access to benzofuro[2,3-b]quinoline and 6H-chromeno[3,4-b]quinoline cores through gold-catalyzed annulation of anthranils with arenoxyethynes and aryl propargyl ethers. Organic and Biomolecular Chemistry 17(18): 4452-4455, 2019

Physicochemical characterization of a new crystal form and improvements in the pharmaceutical properties of the poorly water-soluble antiosteoporosis drug 3,9-bis(N,N-dimethylcarbamoy-loxy)-5H-benzofuro[3,2-c]quinoline-6-one (KCA-098) by solid dispersion with hydroxypropylcellulose. Pharmaceutical Development and Technology 5(4): 443-454, 2000

Isolation and characterization of urinary metabolites of nalorphine in dogs and cats. Journal of Pharmaceutical Sciences 60(1): 148-150, 1971

Effect of KCA-098, a new benzofuroquinoline derivative, on bone mineral metabolism. Biological and Pharmaceutical Bulletin 17(4): 504-508, 1994

Characterization of urinary metabolites of testosterone, methyltestosterone, mibolerone and boldenone in greyhound dogs. Journal of Veterinary Pharmacology and Therapeutics 23(3): 121-129, 2000

Identification of benzofuro[2,3-b]quinoline derivatives as a new class of antituberculosis agents. European Journal of Medicinal Chemistry 45(2): 602-607, 2010

Identification of sulfate and glucuronic acid conjugates of the 5-hydroxy derivative as major metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline in rats. Cancer Research 49(16): 4407-4411, 1989

Inclusion complex of 3,9-bis -5H-benzofuro quinoline-6-one with heptakis -beta-cyclodextrin Interaction and dissolution properties. Biological & Pharmaceutical Bulletin 23(9): 1264-1269, 2000

Identification of new 2-amino-3-methylimidazo[4,5-f]quinoline urinary metabolites from beta-naphthoflavone-treated mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals 37(8): 1690-1697, 2009

A comparative study on the inhibitory effects of 3,9-bis -5H-benzofuro quinoline-6-one and calcitonin on bone resorption in organ culture. Oyo Yakuri 50(1): 79-85, 1995