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Chiral Palladium(II)-catalyzed asymmetric glyoxylate-Ene reaction: alternative approach to the enantioselective synthesis of alpha-hydroxy esters

Chiral Palladium(II)-catalyzed asymmetric glyoxylate-Ene reaction: alternative approach to the enantioselective synthesis of alpha-hydroxy esters

Organic Letters 2(25): 4059-4062

An effective chiral palladium catalyst [Pd(CH(3)CN)(2)(S)-Tol-BINAP](SbF(6))(2) (2b) is developed for asymmetric glyoxylate-ene reactions. This palladium dicationic catalyst provides a simple but efficient approach to the asymmetric synthesis of alpha-hydroxy esters in excellent yields with high enantioselectivities at relatively higher reaction temperature (60 degrees C).

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Accession: 045506860

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PMID: 11112643

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