+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chiral separation and quantitation of pentazocine enantiomers in pharmaceuticals by capillary zone electrophoresis using maltodextrins



Chiral separation and quantitation of pentazocine enantiomers in pharmaceuticals by capillary zone electrophoresis using maltodextrins



Journal of Pharmaceutical and Biomedical Analysis 21(1): 75-81



The chiral separation of pentazocine was achieved by capillary electrophoresis using oligosaccharides. Enantiomers were separated on 100 mM Tris/H3PO4 buffer (pH 2.5) with 5% maltodextrin as a chiral selector, and migration behavior was monitored at 200 nm. Under these conditions, (-)- and (+)-pentazocine and dextromethorphan (internal standard) migrated within 9 min, and the resolution of pentazocine enantiomers was 2.54. Linear calibration curves were obtained in the range 5-50 microg/ml(-1) for each enantiomer. The detection limit of pentazocine enantiomers was 29 pg, and the recoveries of(-)- and (+)-pentazocine were 98.9 (R.S.D., 3.4%) and 101.4% (R.S.D., 4.3%) with 10 microg/ml(-1), respectively.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 045507156

Download citation: RISBibTeXText

PMID: 10701915


Related references

Chiral separation and quantitation of pentazocine enantiomers in pharmaceuticals by capillary zone electrophoresis using maltodextrins. Journal of Pharmaceutical & Biomedical Analysis 21(1): 75-81, 1999

Separation of the enantiomers of coumarinic anticoagulant drugs by capillary electrophoresis using maltodextrins as chiral modifiers. Chirality 6(4): 225-229, 1994

Use of vancomycin as chiral selector in capillary electrophoresis Optimization and quantitation of loxiglumide enantiomers in pharmaceuticals. HRC Journal of High Resolution Chromatography 19(6): 322-332, 1996

Practical aspects in chiral separation of pharmaceuticals by capillary electrophoresis II Quantitative separation of naproxen enantiomers. Journal of Chromatography A 685(1): 155-159, 1994

Chiral separation of abscisic acid enantiomers by capillary zone electrophoresis using cyclodextrins and their derivatives as chiral selectors. Analytical Letters 35(13): 2185-2197, 2002

Chiral capillary electrophoresis as predictor for separation of drug enantiomers in continuous flow zone electrophoresis. Journal of Chromatography A 895(1-2): 51-65, 20 October, 2000

Chiral separation of simendan enantiomers by capillary zone electrophoresis. Chinese Journal of Analytical Chemistry 33(7): 1003-1006, 2005

Capillary zone electrophoresis for separation of drug enantiomers using cyclodextrins as chiral selectors Influence of experimental parameters on separation. Journal of Chromatography A 666(1-2): 337-350, 1994

Chiral separation of pitavastatin calcium enantiomers by capillary zone electrophoresis. Se Pu 28(11): 1089-1093, 2012

Comparison of capillary zone electrophoresis and isotachophoresis determination of dimethindene enantiomers in pharmaceuticals using charged carboxyethyl-beta-cyclodextrin as a chiral selector. Methods and Findings in Experimental and Clinical Pharmacology 28(9): 595-599, 2007

Separation of cefoperazone enantiomers using beta-cyclodextrin as chiral additive by capillary zone electrophoresis. Chirality 16(1): 45-49, 2003

Separation of basic drug enantiomers by capillary zone electrophoresis using ovoglycoprotein as a chiral selector. Journal of Chromatography A 782(2): 281-288, 1997

Chiral separation of cis-trans isomers, astropisomers, and enantiomers acetanilide herbicide metabolites by capillary zone electrophoresis. Abstracts of Papers American Chemical Society 216(1-3): AGRO 1, 1998

Separation of basic drug enantiomers by capillary zone electrophoresis using glucuronyl glucosyl beta-cyclodextrin as a chiral selector. Electrophoresis 22(16): 3382-3388, 2001

Chiral separation of 12 pairs of enantiomers by capillary electrophoresis using heptakis-(2,3-diacetyl-6-sulfato)-β-cyclodextrin as the chiral selector and the elucidation of the chiral recognition mechanism by computational methods. Journal of Separation Science 40(14): 2999-3007, 2017