Home
  >  
Section 46
  >  
Chapter 45,522

Circadian rhythms in plasma cortisone and cortisol and the cortisone/cortisol ratio

Nomura, S.; Fujitaka, M.; Sakura, N.; Ueda, K.

Clinica Chimica Acta; International Journal of Clinical Chemistry 266(2): 83-91

1997

ISSN/ISBN: 0009-8981
PMID: 9437537
DOI: 10.1016/s0009-8981(97)00142-3
Accession: 045521324
Download citation:  
Text
  |  
BibTeX
  |  
RIS
We evaluated the circadian rhythms in the plasma concentrations of cortisol, cortisone and their free forms, and in the cortisone/cortisol ratios by means of reversed-phase high performance liquid chromatography in normal adult subjects. Plasma concentrations of cortisone, as well as cortisol, exhibited a circadian rhythm. The ratios of cortisone/cortisol remained almost constant during the waking hours of normal subjects. Changes in the cortisone/cortisol ratios previously reported in patients with various diseases exceeded the diurnal changes detected in the present study. Thus, the determination of the cortisone/cortisol ratio provides information that is useful in assessing the adrenal function of patients with various diseases.

PDF emailed within 0-6 h: $19.90




Related References

Nomura, S.; Fujitaka, M.; Sakura, N.; Ueda, K. 1997: Circadian rhythms in plasma cortisone and cortisol and the cortisone/cortisol ratio Clinica Chimica Acta 266(2): 83-91,. 31
Zhang, Q.; Chen, Z.; Chen, S.; Xu, Y.; Deng, H. 2017: Intraindividual stability of cortisol and cortisone and the ratio of cortisol to cortisone in saliva, urine and hair Steroids 118: 61-67
Meulenberg, P.M.; Hofman, J.A. 1990: Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum Clinical Chemistry 36(1): 70-75
Ferrante, L. 1970: Cortisol cortico sterone and deoxy cortisol assay in plasma with the trans cortisone cortisol carbon 14 method with glass paper chromatography use in cases of adrenal cortical tumor Zeitschrift für Klinische Chemie und Klinische Biochemie 8(4): 436-437
Nomura, S.; Fujitaka, M.; Jinno, K.; Sakura, N.; Ueda, K. 1996: Clinical significance of cortisone and cortisone/cortisol ratio in evaluating children with adrenal diseases Clinica Chimica Acta; International Journal of Clinical Chemistry 256(1): 1-11
Ray, J.A.; Kushnir, M.M.; Rockwood, A.L.; Meikle, A.W. 2011: Analysis of cortisol, cortisone and dexamethasone in human serum using liquid chromatography tandem mass spectrometry and assessment of cortisol: cortisone ratios in patients with impaired kidney function Clinica Chimica Acta; International Journal of Clinical Chemistry 412(13-14): 1221-1228
Church, D.B.; Emslie, D.R.; Watson, A.D. 1999: Plasma cortisol concentrations following cortisone infusion in dogs before and after treatment with cortisone acetate Australian Veterinary Journal 77(10): 671-673
Eberl, R.; Altmann, H. 1970: Plasma concentration of depot cortisone following cortisone therapy and the influence of this substance on endogenous cortisol production Wiener Klinische Wochenschrift 82(21): 394-396
Weaver, J.U.; Kelly, W.F.; Glenn, C.; Bilous, R.W.; Taylor, N.F.; Wood, P.J. 1996: 11 beta Hydroxysteroid dehydrogenase activity; Serum cortisone/cortisol ratio and 110X0/110H cortisol metabolites in hypopituitarism Journal of Endocrinology 148(Suppl ): P390
Stancáková, A.; Merstenová, E.; Vajó, J.; Valková, M. 1978: The excretion of free cortisol, cortisone, cortisol sulfate and cortisone sulfate in peripheral vascular disease, diabetes mellitus and hyperthyroidism Hormone and Metabolic Research 10(6): 539-544
Colburn, W.A.; Disanto, A.R.; Stubbs, S.S.; Monovich, R.E.; Desante, K.A. 1980: Pharmacokinetic interpretation of plasma cortisol and cortisone concentrations following a signle oral administration of cortisone acetate to human subjects Journal of Clinical Pharmacology 20(7): 428-436
Colburn, W.A.; DiSANTO, A.R.; Stubbs, S.S.; Monovich, R.E.; DeSANTE, K.A. 1980: Pharmacokinetic Interpretation of Plasma Cortisol and Cortisone Concentrations Following a Single Oral Administration of Cortisone Acetate to Human Subjects The Journal of Clinical Pharmacology 20(7): 428-436
Heazelwood, V.J.; Galligan, J.P.; Cannell, G.R.; Bochner, F.; Mortimer, R.H. 1984: Plasma cortisol delivery from oral cortisol and cortisone acetate: relative bioavailability British Journal of Clinical Pharmacology 17(1): 55-59
Tacker, M.M.; Leach, C.S.; Owen, C.A.; Rummel, J.A. 1978: Levels of cortisol, corticosterone, cortisone and 11-deoxycoritsol in the plasma of stressed and unstressed subjects Journal of Endocrinology 76(1): 165-166
Ceccato, F.; Antonelli, G.; Barbot, M.; Zilio, M.; Mazzai, L.; Gatti, R.; Zaninotto, M.; Mantero, F.; Boscaro, M.; Plebani, M.; Scaroni, C. 2014: The diagnostic performance of urinary free cortisol is better than the cortisol:cortisone ratio in detecting de novo Cushing's syndrome: the use of a LC-MS/MS method in routine clinical practice European Journal of Endocrinology 171(1): 1-7
Stancáková, A.; Klimesová, Z. 1979: Urinary free cortisol, cortisone, cortisol sulfate, cortisone sulfate and 17-ketosteroids in breast cancer Neoplasma 26(2): 205-213
Gontscharow, N.P.; Wehrberger, K.; Woronzow, W.I.; Schubert, K. 1972: Steroid metabolism of primates. 13. Isolation of cortisone, tetrahydro-cortisone, tetrahydro-cortisol and allo-tetrahydro-cortisol from the urine of Macacus rhesus and Papio hamadryas Endokrinologie 59(1): 122-126
Grosser, B.I.; Axelrod, L.R. 1968: Conversion of cortisol to cortisol acetate, cortisone acetate and cortisone by the developing primate brain Steroids 11(6): 827-836
Morineau, G.; Boudi, A.; Barka, A.; Gourmelen, M.; Degeilh, F.; Hardy, N.; al-Halnak, A.; Soliman, H.; Gosling, J.P.; Julien, R.; Brerault, J.L.; Boudou, P.; Aubert, P.; Villette, J.M.; Pruna, A.; Galons, H.; Fiet, J. 1997: Radioimmunoassay of cortisone in serum, urine, and saliva to assess the status of the cortisol-cortisone shuttle Clinical Chemistry 43(8 Part 1): 1397-1407
Andersen; Morineau; Fukuda; Westergaard; Ingerslev; Fiet; Byskov 1999: Assessment of the follicular cortisol:cortisone ratio Human Reproduction 14(6): 1563-1568