+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Age at epilepsy onset in patients with focal cortical dysplasias, gangliogliomas and dysembryoplastic neuroepithelial tumours

Age at epilepsy onset in patients with focal cortical dysplasias, gangliogliomas and dysembryoplastic neuroepithelial tumours

Seizure 58: 82-89

The age at epilepsy onset in patients with inborn or very early acquired brain lesions depends on the epileptogenic potential of the lesion and the patients' individual "susceptibility" to epileptic seizures. To gain insight into these determinants, we analysed the case history of patients with focal cortical dysplasias (FCDs) and neuroglial tumours. In a systematic, retrospective analysis comprised of 233 patients who underwent surgery (116 with FCDs and 117 with neuroglial tumours), we evaluated the age at epilepsy onset according to histopathologic subgroups, lesion location and family history. Epilepsy onset was significantly earlier in patients with FCD than for those with neuroglial tumours (FCDs: 8.06 ± 0.74 years, gangliogliomas: 15.86 ± 1.24 years, dysembryoplastic neuroepithelial tumours (DNTs): 19.18 ± 2.47 years; p < 0.00001). FCDs were most frequently located in the frontal, whereas neuroglial tumours most frequently in the temporal lobe. For FCD patients, the age at epilepsy onset was not dependent on lesion location, whereas DNTs in a temporal location were associated with a later epilepsy onset than gangliogliomas and extratemporal DNTs. A positive family history for epilepsy or epileptic seizures was found more frequently among patients with FCDs (FCDs: 20.4%, neuroglial tumours: 8.1%; p = 0.013). We postulate that the age difference at epilepsy onset between patients with FCDs and neuroglial tumours can be attributed - at least partially - to unidentified genetic factors underlying the epileptogenic potential of the brain tissue. Additionally, the large variance in the age at epilepsy onset is possibly also genetically determined.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 045572415

Download citation: RISBibTeXText

PMID: 29677585

DOI: 10.1016/j.seizure.2018.04.002

Related references

Epilepsy surgery for focal cortical dysplasia and dysembryoplastic neuroepithelial tumor. No Shinkei Geka. Neurological Surgery 28(2): 135-144, 2000

MicroRNA519d and microRNA4758 can identify gangliogliomas from dysembryoplastic neuroepithelial tumours and astrocytomas. Oncotarget 9(46): 28103-28115, 2018

Focal cortical dysplasia, dysembryoplastic neuroepithelial tumor and ganglioglioma Relationship with epilepsy. Pathology Research & Practice 191(7-8): 812, 1995

Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours. Neuropathology and Applied Neurobiology 41(6): 743-755, 2016

Dysembryoplastic Neuroepithelial Tumours share with pleomorphic xanthoastrocytomas and gangliogliomas BRAFV600E mutation and expression. 2013

Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy clinical, EEG and neuroimaging features in 100 adult patients. Brain. 118(3): 629-660, 1995

Dysembryoplastic neuroepithelial tumors and gangliogliomas: clinical results of 52 patients. Acta Neurochirurgica 152(10): 1661-1671, 2011

Surgical strategy and outcomes for epileptic patients with focal cortical dysplasia or dysembryoplastic neuroepithelial tumor. Epilepsia 42 Suppl 6: 37-41, 2002

Epilepsy surgery on dysembryoplastic neuroepithelial tumours. Medical Journal of Malaysia 61(3): 374-376, 2007

Comparison of the surgical treatment of epilepsy in patients with cortical dysplasia and dysembryoplastic neuroepithelial tumor lesions over 22 years. Epilepsia 42(Suppl. 7): 303, 2001

Multifocal dysembryoplastic neuroepithelial tumours associated with refractory epilepsy. Epileptic Disorders 16(3): 328-332, 2014

Adult-onset epilepsy associated with dysembryoplastic neuroepithelial tumors. Seizure 17(6): 498-504, 2008

Focal epilepsy associated with dysembryoplastic neuroepithelial tumor in the area of the caudate nucleus. Clinical Neurology and Neurosurgery 114(8): 1119-1122, 2013

Occipital dysembryoplastic neuroepithelial tumor presenting as adult-onset temporal epilepsy. Epilepsy and Behavior Case Reports 8: 92-95, 2017

Frequent association of cortical dysplasia in dysembryoplastic neuroepithelial tumor treated by epilepsy surgery. Surgical Neurology 64(5): 419-427, 2005