+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

A hybrid simulation framework for computer simulation and modelling studies of grating-based x-ray phase-contrast images



A hybrid simulation framework for computer simulation and modelling studies of grating-based x-ray phase-contrast images



Physics in Medicine and Biology 63(14): 14nt03



Clinical studies performed using computer simulation are inexpensive, flexible methods that can be used to study aspects of a proposed imaging technique prior to a full clinical study. Typically, lesions are simulated into (experimental) data to assess the clinical potential of new methods or algorithms. In grating-based phase-contrast imaging (GB-PCI), full wave simulations are, however, computationally expensive due to the high periodicity of the gratings and therefore not practically applicable when large data sets are required. This work describes the development of a hybrid modelling platform that combines analytical and empirical input data for a more rapid simulation of GB-PCI images with little loss of accuracy. Instead of an explicit implementation of grating details, measured summary metrics (i.e. visibility, flux, noise power spectra, presampling modulation transfer function) are applied in order to generate transmission and differential phase images with large fields of view. Realistic transmission and differential phase images were obtained with good quantitative accuracy. The different steps of the simulation framework, as well as the methods to measure the summary metrics, are discussed in detail such that the technique can be easily customized for a given system. The platform offers a fast, accurate alternative to full wave simulations when the focus switches from grating/system design and set up to the generation of GB-PCI images for an established system.

(PDF emailed within 0-6 h: $19.90)

Accession: 045575951

Download citation: RISBibTeXText

PMID: 29938688

DOI: 10.1088/1361-6560/aaceb8


Related references

Volcano modelling and simulation gateway VMSg; a new web-based framework for collaborative research in physical modelling and simulation of volcanic phenomena. Eos, Transactions, American Geophysical Union 90.52, Suppl, 2009

Computer based program modelling the ocular lens to assist with the simulation of images. Investigative Ophthalmology & Visual Science 37(3): S891, 1996

Prospective randomized study of contrast reaction management curricula: computer-based interactive simulation versus high-fidelity hands-on simulation. European Journal of Radiology 82(12): 2247-2252, 2014

Designing the phase grating for Talbot-Lau phase-contrast imaging systems: a simulation and experiment study. Optics Express 24(12): 13357-13364, 2016

A computer program for many-beam image simulation of amplitude-contrast images. Journal of Electron Microscopy Technique 18(4): 429-436, 1991

A method for computer simulation of ultrasound Doppler color flow images--II. Simulation results. Ultrasound in Medicine and Biology 18(10): 873-879, 1992

Investigating the phase transformations in AuCuPd with computer simulation of ion images. Bulletin of the Russian Academy of Sciences: Physics 77(3): 346-348, 2013

Computer simulation of diffraction contrast images and lattice fringe patterns of small hexagonal dislocation loops. Ultramicroscopy 20(3): 279-292, 1986

Ex Vivo Perfusion-Simulation Measurements of Microbubbles as a Scattering Contrast Agent for Grating-Based X-Ray Dark-Field Imaging. Plos One 10(7): E0129512, 2016

Mathematical modelling and computer simulation of aqueous two-phase continuous protein extraction. Journal Of Chromatography A. 741(2): 151-163, 1996

Mathematical modelling and computer simulation of continuous aqueous two-phase protein extraction. Pyle, D L Separations for biotechnology 3 321-328, 1994

Modelling capillary trapping using finite-volume simulation of two-phase flow directly on micro-CT images. Advances in Water Resources 83: 102-110, 2015

Combining patient journey modelling and visual multi-agent computer simulation: a framework to improving knowledge translation in a healthcare environment. Studies in Health Technology and Informatics 204: 25-31, 2015

Crop simulation modelling using a transputer-based parallel computer. Agricultural Systems 35(3): 321-337, 1991

Simulation Training for Residents Focused on Mechanical Ventilation: A Randomized Trial Using Mannequin-Based Versus Computer-Based Simulation. Simulation in Healthcare 12(6): 349-355, 2017