+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Comparison of the effects of a 50% exchange-transfusion with albumin, hetastarch, and modified hemoglobin solutions

Comparison of the effects of a 50% exchange-transfusion with albumin, hetastarch, and modified hemoglobin solutions

Shock 17(1): 61-69

ISSN/ISBN: 1073-2322

PMID: 11795671

DOI: 10.1097/00024382-200201000-00011

We compared the hemodynamic effects of replacing 50% of the blood volume of anesthetized rats with an equal volume of five solutions: human serum albumin (HSA), hetastarch, unmodified hemoglobin, diaspirin-crosslinked hemoglobin, and o-raffinose-crosslinked hemgolobin. Control rats were exchange-transfused with their own blood. HSA and hetastarch caused a severe reduction in systemic vascular resistance (SVR), hypotension, and acute renal failure immediately after the exchange-transfusion. Unmodified and diaspirin-crosslinked hemoglobins caused comparable and severe increases in SVR, whereas vasoconstriction induced by o-raffinose-crosslinked hemoglobin was minimal. The increased SVR induced by all hemoglobin solutions resolved over a 2-day period as the hemoglobin was cleared from plasma. Body weight was monitored for 5 days after the exchange transfusion as a measure of the relative long-term efficacy of the exchange solutions tested and increased substantially in control rats (that received blood). Rats that received both crosslinked hemoglobin solutions gained a comparable amount of weight as the control group. By contrast rats that received HSA, hetastarch and unmodified hemoglobin failed to gain weight or lost weight over the same period. In summary: i) HSA and hetastarch are relatively ineffective as resuscitative fluids when administered after the loss of a large volume of blood; ii) diaspirin-crosslinked hemoglobin causes severe vasoconstriction, comparable in intensity to that induced by unmodified hemoglobin; iii) o-raffinose-crosslinked hemoglobin induces minimal vasoconstriction; iv) the vasoactive effects of all hemoglobin solutions are reversible. We conclude, that of all solutions tested, both the short- and long-term effects of an exchange-transfusion with whole blood are most closely reproduced by an exchange with o-raffinose-crosslinked hemoglobin.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 045597494

Download citation: RISBibTeXText

Related references

A comparison of the acute hemodynamic and delayed effects of 50% exchange transfusion with two different cross-linked hemoglobin based oxygen carrying solutions and Pentastarch. Artificial Cells Blood Substitutes and Immobilization Biotechnology 34(2): 145-157, 2006

Human hemoglobin modified by pyridoxal 5 phosphate and glutaraldehyde in the presence of serum albumin ii. model experiments of exchange transfusion on rats. Biologia (Bratislava) 41(11): 1079-1084, 1986

Fluid resuscitation in circulatory shock: a comparison of the cardiorespiratory effects of albumin, hetastarch, and saline solutions in patients with hypovolemic and septic shock. Critical Care Medicine 11(11): 839-850, 1983

Total exchange transfusion in rats with hemoglobin solutions: influence of hemoglobin concentration. International Journal of Artificial Organs 8(6): 341-344, 1985

Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig. Journal of Pharmacology and Experimental Therapeutics 323(1): 49-60, 2007

Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood. Veterinary Anaesthesia and Analgesia 33(6): 368-380, 2006

Hepatic re function following exchange transfusion with hemoglobin solutions. Biomaterials Artificial Cells and Immobilization Biotechnology 19(2): 409, 1991

Hemoglobin-albumin cluster: physiological responses after exchange transfusion into rats and blood circulation persistence in dogs. Artificial Cells Nanomedicine and Biotechnology 46(Sup3): S621-S629, 2018

Renal and systemic-hemodynamic response to isovolemic exchange transfusion with hemoglobin cross-linked with bis (3,5-dibromosalicyl) fumarate or albumin. Journal of Laboratory and Clinical Medicine 126(3): 250-260, 1995

Coronary flow dynamics in swine following partial exchange transfusions with hemoglobin and albumin solutions. Biomaterials Artificial Cells and Artificial Organs 16(1-3): 355-356, 1988

The physiological and histopathological response of dogs to exchange transfusion with polyethylene glycol-modified bovine hemoglobin (PEG-Hb). Artificial Cells Blood Substitutes and Immobilization Biotechnology 24(6): 655-683, 1996

Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks. Transfusion 46(3): 339-347, 2006

Effect of polyethylene glycol modified bovine hemoglobin in the conscious porcine extreme exchange transfusion model. FASEB Journal 8(4-5): A841, 1994

Colloid Osmotic Pressure and Fluid Resuscitation with Hetastarch, Albumin, and Saline Solutions. Survey of Anesthesiology 26(6): 332-333, 1982

Colloid osmotic pressure and fluid resuscitation with hetastarch, albumin, and saline solutions. Critical Care Medicine 10(3): 159-162, 1982