Comparison of the in-vitro activity of voriconazole (UK-109,496) , itraconazole and amphotericin B against clinical isolates of Aspergillus fumigatus
Cuenca-Estrella, M.; Rodríguez-Tudela, J.L.; Mellado, E.; Martínez-Suárez, J.V.; Monzón, A.
Journal of Antimicrobial ChemoTherapy 42(4): 531-533
ISSN/ISBN: 0305-7453 PMID: 9818755 DOI: 10.1093/jac/42.4.531
Voriconazole was compared with amphotericin B and itraconazole by a modification of the NCCLS microdilution reference method for yeasts against 62 clinical isolates of Aspergillus fumigatus. MICs of voriconazole were slightly lower than those of amphotericin B and itraconazole. The MIC of voriconazole at which 90% of isolates were inhibited was 1 mg/L and the MIC range was 0.25-2 mg/L. Voriconazole is a new antifungal agent with potential for use in the treatment of A. fumigatus infections.