Section 46
Chapter 45,599

Comparison of the in-vitro activity of voriconazole (UK-109,496) , itraconazole and amphotericin B against clinical isolates of Aspergillus fumigatus

Cuenca-Estrella, M.; Rodríguez-Tudela, J.L.; Mellado, E.; Martínez-Suárez, J.V.; Monzón, A.

Journal of Antimicrobial ChemoTherapy 42(4): 531-533


ISSN/ISBN: 0305-7453
PMID: 9818755
DOI: 10.1093/jac/42.4.531
Accession: 045598059

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Voriconazole was compared with amphotericin B and itraconazole by a modification of the NCCLS microdilution reference method for yeasts against 62 clinical isolates of Aspergillus fumigatus. MICs of voriconazole were slightly lower than those of amphotericin B and itraconazole. The MIC of voriconazole at which 90% of isolates were inhibited was 1 mg/L and the MIC range was 0.25-2 mg/L. Voriconazole is a new antifungal agent with potential for use in the treatment of A. fumigatus infections.

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