+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Considerations upon the anatomical model of reward-based learning in the basal ganglia



Considerations upon the anatomical model of reward-based learning in the basal ganglia



Medical Hypotheses 54(3): 397-399



The nigrostriatal pathway appears to be very important in the reward-based learning. The dopaminergic neurons in the substantia nigra pars compacta (SNC) fire in relation to primary rewards and reward-conditioned stimuli, but not to rewards that are expected. It has been hypothesized that the anatomical framework for the selective response of these neurons is organized in the projections from some paralimbic areas in the frontal lobe to the striosomes of the caudate nucleus, which are also directly connected with the dopaminergic neurons of the SNC. Here, we present two additional pathways that may be related with this neurophysiological finding. We hypothesize that the connections of the paralimbic cortices with the ventral system of the basal ganglia and then with the thalamus and the hypothalamus, and the circuit ventral striatum-substantia nigra pars reticulata-thalamus-striatum could be also involved in the reward-based learning.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 045628925

Download citation: RISBibTeXText

PMID: 10783473


Related references

An extended reinforcement learning model of basal ganglia to understand the contributions of serotonin and dopamine in risk-based decision making, reward prediction, and punishment learning. Frontiers in Computational Neuroscience 8: 47, 2014

Neuromodulatory adaptive combination of correlation-based learning in cerebellum and reward-based learning in basal ganglia for goal-directed behavior control. Frontiers in Neural Circuits 8: 126, 2014

Focal basal ganglia lesions are associated with impairments in reward-based reversal learning. Brain 131(Pt 3): 829-841, 2008

Vascular Risk Factors and Diseases Modulate Deficits of Reward-Based Reversal Learning in Acute Basal Ganglia Stroke. Plos one 11(5): E0155267, 2016

Learning Reward Uncertainty in the Basal Ganglia. Plos Computational Biology 12(9): E1005062, 2016

A network model of basal ganglia for understanding the roles of dopamine and serotonin in reward-punishment-risk based decision making. Frontiers in Computational Neuroscience 9: 76, 2015

Integrating cortico-limbic-basal ganglia architectures for learning model-based and model-free navigation strategies. Frontiers in Behavioral Neuroscience 6: 79, 2012

Where is my reward and how do I get it? Interaction between the hippocampus and the basal ganglia during spatial learning. Journal of Physiology Paris 106(3-4): 72-80, 2012

The role of the basal ganglia in exploration in a neural model based on reinforcement learning. International Journal of Neural Systems 16(2): 111-124, 2006

Processing of reward information in primate basal ganglia follows associative learning rules. Elsner, N, Menzel, R Learning and memory 68, 1995

Anatomical considerations in basal ganglia surgery. Lozano, Andres M [Author] Progress in Neurological Surgery; Movement disorder surgery 21-30, 2000

The basal ganglia; anatomical, clinical and surgical considerations. Bulletin. Georgetown University. Medical Center 3(1): 7, 1949

Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. European Journal of Neuroscience 28(8): 1437-1448, 2008

Computing reward-prediction error: an integrated account of cortical timing and basal-ganglia pathways for appetitive and aversive learning. European Journal of Neuroscience 42(4): 2003-2021, 2015

Involvement of the basal ganglia in reward- and punishment-based action selection. Neuroscience Research Suppl. (26): S7, 2002( ), 2003