+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Corticobasal degeneration and progressive supranuclear palsy--differentiation by somatosensory-evoked potentials



Corticobasal degeneration and progressive supranuclear palsy--differentiation by somatosensory-evoked potentials



No to Shinkei 48(3): 253-257



It is by no means easy to make an early differential diagnosis between corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), because both disorders occasionally show similar clinical features such as parkinsonism, supranuclear gaze palsy, or dementia. In the present study, we studied somatosensory-evoked potentials (SEPs) in 4 CBD and 8 PSP patients. SEPs after median nerve stimulation (0.2 ms square wave delivered with a frequency of 1 Hz) were recorded from bilateral parietal and midfrontal electrodes. Latencies of identifiable peaks and the inter-peak amplitudes were measured, and a comparison was made between the two disorders. Both latencies and amplitudes of all the identified peaks showed no statistical difference between the two disorders. To reveal an inter-hemispheric difference of the amplitude, we calculated the asymmetry index: the amplitude of the more affected side/the sum of the amplitudes of both sides. In CBD patients, an asymmetry index of P1N2 amplitude was found to be decreased significantly. The asymmetric appearance of this part of SEPs may be helpful for early differential diagnosis between CBD and PSP.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 045658554

Download citation: RISBibTeXText

PMID: 8868336


Related references

Visual event-related potentials in progressive supranuclear palsy, corticobasal degeneration, striatonigral degeneration, and Parkinson's disease. Journal of Neurology 247(5): 356-363, 2000

Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. Journal of Neurology 246(Suppl. 2): II/6-II/15, 1999

An unusual autopsy case of corticobasal degeneration--with special reference to clinicopathological differentiation from progressive supranuclear palsy and slowly progressive aphasia. No to Shinkei 48(6): 559-565, 1996

Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: Differentiation from progressive supranuclear palsy. Acta Neuropathologica 90(1): 37-43, 1995

Somatosensory evoked potentials in progressive supranuclear palsy. Journal of the Neurological Sciences 179(1-2): 85-91, 2000

Corticobasal degeneration: widespread argentophilic threads and glia in addition to neurofibrillary tangles. Similarities of cytoskeletal abnormalities in corticobasal degeneration and progressive supranuclear palsy. Journal of the Neurological Sciences 138(1-2): 66-77, 1996

Progressive supranuclear palsy and corticobasal ganglionic degeneration: differentiation by clinical features and neuroimaging techniques. Journal of Neural Transmission. Supplementum 42: 79-90, 1994

Enlargements of somatosensory-evoked potentials in progressive supranuclear palsy. Acta Neurologica Scandinavica 106(4): 209-212, 2002

Progressive supranuclear palsy and corticobasal degeneration. Bailliere's Clinical Neurology 6(1): 167-185, 1997

Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration. Journal of Neuropathology and Experimental Neurology 60(6): 647-657, 2001

Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: Tau pathologies with exclusively exon 10 isoforms. Journal of Neurochemistry 72(3): 1243-1249, 1999