+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

Cell 78(2): 343-352

ISSN/ISBN: 0092-8674

PMID: 8044845

DOI: 10.1016/0092-8674(94)90303-4

Interleukin-1 beta-converting enzyme (ICE) proteolytically cleaves pro-IL-1 beta to its mature, active form. The crystal structure at 2.5 A resolution of a recombinant human ICE-tetrapeptide chloromethylketone complex reveals that the holoenzyme is a homodimer of catalytic domains, each of which contains a p20 and a p10 subunit. The spatial separation of the C-terminus of p20 and the N-terminus of p10 in each domain suggests two alternative pathways of assembly and activation in vivo. ICE is homologous to the C. elegans cell death gene product, CED-3, and these may represent a novel class of cytoplasmic cysteine proteases that are important in programmed cell death (apoptosis). Conservation among members of the ICE/CED-3 family of the amino acids that form the active site region of ICE supports the hypothesis that they share functional similarities.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 045677766

Download citation: RISBibTeXText

Related references

Crystal structure of the cysteine protease interleukin-1b-converting enzyme: a (p20/p10)2 homodimer. Cell 78: 3-52, 1994

Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3. Genomics 40(1): 86-93, 1997

Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme. European Journal of Biochemistry 236(1): 207-213, 1996

Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death. Protein Science: a Publication of the Protein Society 4(1): 3-12, 1995

Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3. Oncogene 13(4): 749-755, 1996

Inhibitors of cysteine protease interleukin-1-beta-converting enzyme abolish the apoptosis of ST-1 cells induced by nephrotoxicant pesticides. Journal of the American Society of Nephrology 7(9): 1843, 1996

Purification and characterization of an interleukin-1b-converting enzyme family protease that activates cysteine protease P32. The Journal of Biological Chemistry 271: 371-6, 1996

Purification and characterization of an interleukin-1beta-converting enzyme family protease that activates cysteine protease P32 (CPP32). Journal of Biological Chemistry 271(23): 13371-13376, 1996

Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains. Journal of Biological Chemistry 270(30): 18044-18050, 1995

Identification of a cysteine protease closely related to interleukin-1b-converting enzyme. European Journal of Biochemistry 236: 7-13, 1996

Identification of a Cysteine Protease Closely Related to Interleukin-1β-Converting Enzyme. Febs Journal 236(1): 207-213, 1996

Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor. Archives of Biochemistry and Biophysics 296(2): 698-703, 1992

Identification and mapping of Casp7, a cysteine protease resembling CPP32β, interleukin-1β converting enzyme, and CED-3. Genomics (San Diego, Calif.) 40(1): 86-93, 1997

The interleukin-1 beta converting enzyme family of cysteine proteases. Journal of Cellular Biochemistry 64(1): 2-10, 1997

Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. Journal of Experimental Medicine 185(4): 601-607, 1997