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Determination of nifedipine content and its uniformity in tablets by high performance liquid chromatography


Determination of nifedipine content and its uniformity in tablets by high performance liquid chromatography



Se Pu 17(3): 308-309



ISSN/ISBN: 1000-8713

PMID: 12549138

An HPLC method with diazepam as internal standard was developed to determine nifedipine content and its uniformity in tablets. The analytical column was a C18 column, the mobile phase consisted of V (methanol):V(triethylamine, pH 5.20) = 68:32. The detection was carried out with UV detector (lambda = 237 nm). Under this condition, the linear range was wide(8-80 mg/L) and the recovery was high (99.86%). The proposed method is simple and accurate and the decomposed product can be separated as well. Therefore, the quality of nifedipine tablets can be effectively controlled.

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Accession: 045748350

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