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Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector



Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector



Journal of Capillary Electrophoresis 2(5): 213-217



Capillary zone electrophoresis (CZE) was used for the enantiomeric separation of (R,S)-tiaprofenic acid ([R,S]-Tia) in a pharmaceutical formulation employing an acetate buffer at pH 4.5 and 2,3,6-tri-O-methyl-beta-cyclodextrin (tri-OMe-beta-CD) as the chiral selector. The effect of the concentration of trimethylated-beta-cyclodextrin in the presence of carboxymethylated-beta-cyclodextrin (CM-beta-CD) on enantiomeric resolution of (R,S)-Tia and (R,S)-5-benzoyl-alpha-methyl-3-thiopheneacetic acid (3-isomer of tiaprofenic acid, 3-Tia) was investigated at pH 4, 4.5, and 5.

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Accession: 045797287

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PMID: 9384778


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