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Dolastatin 3 and two novel cyclic peptides from a palauan collection of Lyngbya majuscula

Mitchell, S.S.; Faulkner, D.J.; Rubins, K.; Bushman, F.D.

Journal of Natural Products 63(2): 279-282

2000


ISSN/ISBN: 0163-3864
PMID: 10691729
DOI: 10.1021/np990353f
Accession: 045827141

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A collection of Lyngbya majuscula from Palau contained the peptides dolastatin 3 (1), homodolastatin 3 (2), and kororamide (3), together with aplysiatoxin (4), debromoaplysiatoxin (5), and oscillatoxin A (6). The structures of the new peptides homodolastatin 3 (2) and kororamide (3) were determined by interpretation of spectroscopic data and chemical degradation.

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