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Dyslipidemia-related risk factors for myocardial infarction and polymorphism of ApoE gene among myocardial infarction patients and their siblings



Dyslipidemia-related risk factors for myocardial infarction and polymorphism of ApoE gene among myocardial infarction patients and their siblings



Zhonghua Yi Xue Za Zhi 81(6): 340-343



To assess the risk factors of myocardial infarction (MI) and the polymorphism of the gene Apoliprotein (ApoE) genotype among MI patients and their siblings. Questionnaire survey and clinical examination were conducted to 65 male MI patients, 141 "healthy" male siblings of the MI patients, and 47 healthy persons matched in age and sex. (1) The medians of TC, TG, LDL-C, TC/HDL-C in MI group and sibling group were higher than those in the control group with statistical significance. (2) BMI > 25 kg/m(2), cigarette > 10/d, TC > 5.2 mmol/L, TG > 2.26 mmol/L, LDL-C > 3.4 mmol/L, TC/HDL-C > 5.0, and FBG > 5.6 mmol/L were risk factors for MI; and HDL-C > 0.9 mmol/L was a protective factor for MI. (3) Among the three genotypes of ApoE, E3/3 was the commonest one. However, no significant difference was found in the distribution frequencies of these 3 genotypes, levels of serum lipid and lipoprotein, and TC/HDL-C. (4) Among the MI patients the number of allele E4 carrier was nearly twice the number of the non-allele E4 carrier. Dyslipidemia is an important risk factor for MI, and polymorphism of ApoE may be an indirect risk factor of coronary heart disease genetically.

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Accession: 045849239

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PMID: 11798896


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