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Effect of hemodialysis on left ventricular function in patients with chronic renal failure assessment with radionuclide ventriculography



Effect of hemodialysis on left ventricular function in patients with chronic renal failure assessment with radionuclide ventriculography



Polskie Archiwum Medycyny Wewnetrznej 90(3): 185-191



To examine the effects of haemodialysis (HD) on left ventricular (LV) function, gated radionuclide ventriculography was conducted before and after HD in 16 patients with chronic renal failure (CRF) and in 12 healthy persons. The LV sectorial function was assessed by subdividing the LV region of interest into 6 sectors. Global ejection fraction (EF) was unchanged by dialysis (61.4 +/- 8.3% before vs. 63.5 +/- 10.4% after) (mean +/- S.D.). EF of sectors 4 and 5 was improved significantly (69.3 +/- 10.7% and 85.6 +/- 17.1% before vs. 81.7 +/- 18.4% and 97.4 +/- 22.0% after) (p < 0.05 and p < 0.05). The peak ejection rate (PER) was increased following HD (3.07 +/- 1.03 EDc/s before vs. 3.88 +/- 0.88 EDc/s after) (p < 0.02). The time to end systole (TES) corrected for R-R interval was unchanged by HD (46.3 +/- 6.3 before vs. 43.8 +/- 5.3 after). The peak filling rate (PFR) was unchanged by HD (3.41 +/- 0.77 EDc/s before vs. 3.05 +/- 0.45 EDc/s after). The time to peak filling rate (TPFR) corrected for R-R interval was increased (21.8 +/- 5.3 before vs 25.9 +/- 5.0 after) (p < 0.02). This study indicates that HD produces beneficial effects on LV systolic function in CRF patients and does not improve LV filling in early diastole.

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Accession: 045880311

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PMID: 8284242


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