+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of meal size and test duration on gastric emptying and gastric myoelectrical activity as determined with simultaneous [13C]octanoate breath test and electrogastrography in normal subjects using a muffin meal



Effect of meal size and test duration on gastric emptying and gastric myoelectrical activity as determined with simultaneous [13C]octanoate breath test and electrogastrography in normal subjects using a muffin meal



Digestive Diseases and Sciences 46(12): 2643-2650



Our purpose was to determine the effect of meal size on gastric emptying (GE) as measured by octanoate breath test (OBT), to determine the effect of the duration of breath collections on assessment of GE by OBT, and to determine the effect of meal size on gastric myoelectrical activity as measured by electrogastrography (EGG). Fourteen normal subjects underwent two modified [13C]OBTs using muffin meals of 250 or 350 kcal mixed with 100 mg [13C]sodium octanoate. T(1/2) for GE was determined for both the entire postprandial 6-hr breath collection and a truncated initial 4-hr data set. EGG was recorded for 30 min prior to the muffin meal and 4 hr postprandially. Using the 6-hr breath collection data, the T(1/2) was 177 +/- 7 (mean +/- SEM) for the 350-kcal meal compared to 153 +/- 7 min (P < 0.01) for the 250-kcal meal. Using the 4-hr data, the T(1/2) for the 350-kcal meal was 244 +/- 32 min compared to 165 +/- 12 min (P < 0.05) for the 250-kcal meal. The ratio of postprandial to fasting EGG power of the dominant frequency for the 350-kcal meal (1.9 +/- 0.4) was higher than that for the 250-kcal meal (1.3 +/- 0.6). T(1/2) for the 350-kcal meal using 4- and 6-hr data was significantly correlated with the 4-hr power ratio (r = 0.68 and 0.67; P < 0.05, respectively), but poorly correlated for the 250-kcal meal. In conclusions, GE and EGG are affected by meal size. Using the muffin-based [13C]OBT, T(1/2) for the 350-kcal meal was significantly longer than for a 250-kcal meal. Longer T(1/2) values were obtained with shorter breath sampling durations. The postprandial to fasting power ratio for the 350-kcal meal was greater than that for the 250-kcal meal.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 045884273

Download citation: RISBibTeXText

PMID: 11768254


Related references

Effect of meal size and test duration on gastric emptying as determined by breath test in normal subjects using a muffin meal labeled with 13C-sodium octanoate. Gastroenterology 118(4 Suppl 2 Part 1): AGA A143, 2000

Simultaneous measurement of gastric emptying with a simple muffin meal using octanoate breath test and scintigraphy in normal subjects and patients with dyspeptic symptoms. Digestive Diseases and Sciences 47(7): 1657-1663, 2002

Delayed gastric emptying of a solid and a liquid test meal in patients with idiopathic parkinsons disease by using a non invasive 13c octanoate breath test and 13c acetate breath test. Digestive Disease Week Abstracts & Itinerary Planner : Abstract No W1466, 2003

Impaired gastric emptying of a solid test meal in patients with Parkinson's disease using 13C-sodium octanoate breath test. Neuroscience Letters 375(3): 170-173, 2005

Gastric emptying characteristics of a novel muffin meal Comparison of 13C-octanoate breath testing and scintigraphy. Gastroenterology 116(4 Part 2): A971, 1999

Measurement of solid phase gastric emptying with a simplified muffin meal using breath testing with either 13C-octanoate or 13C-acetate. Gastroenterology 120(5 Suppl. 1): A 466, 2001

Gastric emptying of BIPS in normal dogs with simultaneous solid-phase gastric emptying of a test meal measured by nuclear scintigraphy. Veterinary Radiology and Ultrasound 41(4): 381-383, 2000

Gastric emptying characteristics of a novel (13)C-octanoate-labeled muffin meal. Journal of Clinical Gastroenterology 32(5): 394-399, 2001

Octanoic acid breath test for gastric emptying of solids Meal-to-meal variability. Gastroenterology 114(4 Part 2): A765, 1998

Gastric emptying of a solid meal starts during meal ingestion: combined study using 13C-octanoic acid breath test and Doppler ultrasonography. Absence of a lag phase in 13C-octanoic acid breath test. Digestion 70(1): 55-60, 2004

T1339 A Stable Isotope Breath Test with a Standard Meal for Abnormal Gastric Emptying of Solids in the Clinic and in Research: Validation in 167 Subjects. Gastroenterology 134(4): A-534, 2008

The utility of noninvasive (13)C-acetate breath test using a new solid test meal to measure gastric emptying in mice. Journal of Smooth Muscle Research 44(5): 159-165, 2008

The 13C-acetate breath test for the noninvasive assessment of the gastric emptying of a liquid/solid test meal in diabetics. Deutsche Medizinische Wochenschrift 121(22): 713-718, 1996

A test meal suitable for measuring gastric emptying of solids by means of a -sodium acetate breath test. Proceedings of the Nutrition Society 60(OCA): 9A, Spring, 2001

(13)C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer): Toward standardization for testing gastric emptying of solids. Digestive and Liver Disease 42(8): 549-553, 2010