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Efficient synthesis of the C (1) -C (11) fragment of the tedanolides. the nonaldol aldol process in synthesis

Jung, M.E.; Marquez, R.

Organic Letters 2(12): 1669-1672

2000

ISSN/ISBN: 1523-7060
PMID: 10880197
DOI: 10.1021/ol005675l
Accession: 045930906
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[reaction: see text] The nonaldol aldol process developed in our laboratories has been applied to the synthesis of a C(1)-C(11) fragment 22 of the novel macrocyclic cytotoxic agents tedanolide and 13-deoxytedanolide 1 and 2. The commercially available hydroxy ester 7 was converted in 24 steps into compound 22 using two nonaldol aldol reactions.

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Related References

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