Efficient synthesis of the C (1) -C (11) fragment of the tedanolides. the nonaldol aldol process in synthesis
Jung, M.E.; Marquez, R.
Organic Letters 2(12): 1669-1672
[reaction: see text] The nonaldol aldol process developed in our laboratories has been applied to the synthesis of a C(1)-C(11) fragment 22 of the novel macrocyclic cytotoxic agents tedanolide and 13-deoxytedanolide 1 and 2. The commercially available hydroxy ester 7 was converted in 24 steps into compound 22 using two nonaldol aldol reactions.