Section 46
Chapter 45,933

Oestrogen receptor status predicts local recurrence following breast conservation surgery for early breast cancer

Yaghan, R.; Stanton, P.D.; Robertson, K.W.; Going, J.J.; Murray, G.D.; McArdle, C.S.

European Journal of Surgical Oncology the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 24(5): 424-426


ISSN/ISBN: 0748-7983
PMID: 9800972
DOI: 10.1016/s0748-7983(98)92341-1
Accession: 045932982

To evaluate factors predicting locoregional recurrence in patients treated for early breast carcinoma by breast conservation surgery with or without radiotherapy. A retrospective study of 256 patients was carried out, with special emphasis on the role of oestrogen receptor status. Other parameters studied included age, menopausal status, size of primary tumour, tumour type, axillary nodal status and adjuvant therapy. Multivariate analysis showed the following parameters to be independent predictors of locoregional recurrence. Radiotherapy (57% reduction in hazard, P = 0.004): expression of oestrogen receptors (52% reduction in hazard, P = 0.008); tamoxifen therapy (46% reduction in hazard, P = 0.023); tumour size (40% increase in hazard per cm, P<0.001). Within this study, lack of oestrogen receptor expression was a strong independent factor associated with a higher rate of locoregional recurrence. This may be of value in selecting a group of patients less suitable for breast conservation surgery.

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