+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Altered Cerebral Perfusion in Infants Born Preterm Compared with Infants Born Full Term



Altered Cerebral Perfusion in Infants Born Preterm Compared with Infants Born Full Term



Journal of Pediatrics 193: 54-61.E2



To compare regional cerebral cortical blood flow (CBF) in infants born very preterm at term-equivalent age (TEA) and healthy newborns born full term and to examine the impact of clinical risk factors on CBF in the cohort born preterm. This prospective, cross-sectional study included infants born very preterm (gestational age at birth <32 weeks; birth weight <1500 g) and healthy infants born full term. Using noninvasive 3T arterial spin labeling magnetic resonance imaging, we quantified regional CBF in the cerebral cortex: sensorimotor/auditory/visual cortex, superior medial/dorsolateral prefrontal cortex, anterior cingulate cortex (ACC)/posterior cingulate cortex, insula, and lateral posterior parietal cortex, as well as in the brainstem, and deep gray matter. Analyses were performed controlling for sex, gestational age, and age at magnetic resonance imaging. We studied 202 infants: 98 born preterm and 104 born full term at TEA. Infants born preterm demonstrated greater global CBF (β = 9.03; P < .0001) and greater absolute regional CBF in all brain regions except the insula. Relative CBF in the insula, ACC and auditory cortex were decreased significantly in infants born preterm compared with their peers born at full term (P < .0001; P = .026; P = .036, respectively). In addition, the presence of parenchymal brain injury correlated with lower global and regional CBF (insula, ACC, sensorimotor, auditory, and visual cortices) whereas the need for cardiac vasopressor support correlated with lower regional CBF in the insula and visual cortex. Altered regional cortical CBF in infants born very preterm at TEA may reflect early brain dysmaturation despite the absence of cerebral cortical injury. Furthermore, specific cerebral cortical areas may be vulnerable to early hemodynamic instability and parenchymal brain injury.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 045986087

Download citation: RISBibTeXText

PMID: 29212618

DOI: 10.1016/j.jpeds.2017.09.083


Related references

PIH8 Medication Use and Hospital Admission Rates among Preterm Born Infants Compared to Full Term Born Infants. Value in Health 15(4): A192-A193, 2012

Muscle tendon unit comparisons between infants born preterm and infants born full term: a pilot study. Pediatric Physical Therapy 19(4): 309-314, 2007

Infants born preterm exhibit different patterns of center-of-pressure movement than infants born at full term. Physical Therapy 89(12): 1354-1362, 2010

Comparison of active motor items in infants born preterm and infants born full term. Pediatric Physical Therapy 18(3): 197-203, 2006

Spontaneous dna synthesis of blood lymphoid cells in new born and older premature infants and in full term new born infants. Zeitschrift fuer Kinderheilkunde 117(4): 319-320, 1974

Status at school entry for infants 801 g birth weight compared to heavier preterm and term infants born in 1990s. Pediatric Research. 51(4 Part 2): 409a-410a, Il, 2002

Comparative analysis of fecal microflora of healthy full-term Indian infants born with different methods of delivery vaginal vs cesarean Acinetobacter sp prevalence in vaginally born infants. Journal of Biosciences 37(1 Suppl.): 989-998, 2012

Comparative analysis of fecal microflora of healthy full-term Indian infants born with different methods of delivery (vaginal vs cesarean): Acinetobacter sp. prevalence in vaginally born infants. Journal of Biosciences 37(6): 989-998, 2013

Effect of intra venous l alanine administration on plasma glucose insulin and glucagon blood pyruvate lactate and beta hydroxy butyrate concentrations in new born infants study in term and preterm new born infants. Acta Paediatrica Scandinavica 67(3): 297-302, 1978

The visual and auditory evoked responses in full term and preterm new born infants. Electroencephalography & Clinical Neurophysiology 45(1): 4P, 1978

A study of the Biernacky reaction erythrocyte sedimentation rate in new-born infants born at full term. Ann Univ Mariae Curie Sklodowska Sect D Med 4d(3): 431-441, 1949

The performance of infants born preterm and full-term in the mobile paradigm: learning and memory. Physical Therapy 84(9): 808-821, 2004

Cerebro spinal fluid protein concentration in preterm and full term new born infants. Acta Paediatrica Academiae Scientiarum Hungaricae 23(1): 1-8, 1982

The relative kicking frequency of infants born full-term and preterm during learning and short-term and long-term memory periods of the mobile paradigm. Physical Therapy 85(1): 8-18, 2004

Behavioral changes and bio electric brain maturation of preterm and full term new born infants a polygraphic study. Developmental Medicine & Child Neurology 24(1): 30-47, 1982