+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Evaluation of inhalational anaesthetics on murine in vitro fertilization



Evaluation of inhalational anaesthetics on murine in vitro fertilization



Annals of the Academy of Medicine, Singapore 23(4): 479-485



Chronic exposure to inhalational anaesthetics has been implicated in producing adverse reproductive effects in exposed personnel. A longer duration of general anaesthesia during laparoscopic oocyte retrieval for human in vitro fertilization programmes was associated with a decrease in fertilization and cleavage rates. In this study, a mouse model was used to evaluate the effects of clinical concentrations of nitrous oxide, isoflurane and halothane on in vitro fertilization. Mouse oocytes were exposed to 3 inhalational anaesthetic mixtures, oxygen/nitrous oxide, oxygen/nitrous/isoflurane 0.5% or oxygen/nitrous oxide/halothane 0.5% just prior to insemination and their subsequent development was assessed. The fertilization (2-cell) rate and early embryonic growth rate, i.e., 4-cell and morula rates were not statistically different from those of controls which were exposed to air. This study showed that short exposures to clinical concentrations of nitrous oxide, isoflurane and halothane had no deleterious effect on in vitro fertilization and early embryonic growth up to the morula stage in the mouse. Their effects on subsequent implantation and foetal teratogenecity are unknown.

(PDF emailed within 1 workday: $29.90)

Accession: 046010629

Download citation: RISBibTeXText

PMID: 7979122


Related references

Inhalational anaesthetics in the ICU: theory and practice of inhalational sedation in the ICU, economics, risk-benefit. Best Practice & Research. Clinical Anaesthesiology 19(3): 523-538, 2005

The influence of inhalational anaesthetics on the oxidative drug metabolism in vitro and in vivo. Naunyn-Schmiedeberg's Archives of Pharmacology 287 Suppl: R79-R79, 1975

New inhalational anaesthetics. Anaesthesist 45(8): 674-693, 1996

Inhalational anaesthetics. 2012

Inhalational anaesthetics: an update. Acta Anaesthesiologica Belgica 47(1): 3-6, 1996

Halogenated inhalational anaesthetics. Best Practice & Research. Clinical Anaesthesiology 17(1): 29-46, 2003

Inhalational anaesthetics and cardioprotection. Handbook of Experimental Pharmacology: 187-207, 2008

Pharmacokinetics Of Inhalational Anaesthetics. Lancet 2(7351): 143-145, 1964

The newer inhalational anaesthetics. Practitioner 161(965): 361-371, 1948

Update on inhalational anaesthetics. Current Opinion in Anaesthesiology 22(4): 491-495, 2009

Occupational exposure to inhalational anaesthetics. Anaesthesia 52(7): 714-714, 1997

Clinical pharmacokinetics of the inhalational anaesthetics. Clinical Pharmacokinetics 12(3): 145-167, 1987

Mechanisms of action of inhalational anaesthetics. South African Journal of Medical Sciences 41(4): 305-326, 1976

Occupational hazards of inhalational anaesthetics. Best Practice & Research. Clinical Anaesthesiology 17(1): 147-161, 2003

Biotransformation and toxicity of inhalational anaesthetics. Canadian Journal of Anaesthesia 37(4 Pt 2): Scxvi-Scxxiii, 1990