+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Evaluation of inner ear histology and auditory brainstem response in Wriggle Mouse Sagami

Evaluation of inner ear histology and auditory brainstem response in Wriggle Mouse Sagami

Acta Oto-Laryngologica 119(7): 767-772

Wriggle Mouse Sagami (WMS) is a spontaneous mutant strain with neuroepithelial defects. These animals are characterized by abnormal movements linked to an autosomal recessive gene. To determine the association between inner ear histology and hearing ability, we assayed these characteristics in mice homozygous and heterozygous for the mutation, as well as in wild-type animals. In homozygotes, the cochlea and saccule degenerated 3 months after birth. Beginning at 3 months of age, and progressing in an age-dependent manner, the organ of Corti disappeared and the number of spiral ganglion cells decreased, starting at the basal turn and moving toward the apical turn. The sensory epithelium became atrophic in the saccule. Three-month-old heterozygotes demonstrated degeneration in the cochlea, not in the saccule. No obvious auditory brainstem evoked response (ABR) was observed at any frequency in homozygotes aged 1 month and older. In contrast, the heterozygotes retained some hearing acuity until the age of 1 month, after which they became deaf. These findings suggest that WMS mice may provide a good model that will be useful in identifying deafness genes in humans.

(PDF emailed within 1 workday: $29.90)

Accession: 046010638

Download citation: RISBibTeXText

PMID: 10687933

Related references

Neurochemical aspects of wriggle mouse sagami. Japanese Journal of Pharmacology 49(SUPPL): 86P, 1989

Amino acid-induced responses in CNS neurones of normal mouse and Wriggle Mouse Sagami. Neuroreport 5(12): 1530-1532, 1994

Behavioral effects of ceruletide in Wriggle Mouse Sagami--in comparison with in Rolling Mouse Nagoya. Jikken Dobutsu. Experimental Animals 38(1): 61-64, 1989

Substance p like immunoreactivity in the central nervous system of wriggle mouse sagami an ataxic mutant mouse. Biomedical Research 11(6): 433-436, 1990

Abnormal synaptic architecture in the cerebellar cortex of a new dystonic mutant mouse, Wriggle Mouse Sagami. Neuroscience Research. 16(1): 39-48, 1993

Functional difference in monoamine transmitters in the behaviorally abnormal mouse mutant (wriggle mouse sagami). Neuroscience Letters 103(3): 343-348, 1989

Behavioral pharmacological investigation of wriggle mouse sagami. Experimental Animals 37(1): 81-84, 1988

Behavioral pharmacology investigation of the wriggle mouse Sagami. Jikken Dobutsu. Experimental Animals 37(1): 81-83, 1988

Fundamental study on ataxic mice (wriggle mouse Sagami). Jikken Dobutsu. Experimental Animals 36(2): 185-189, 1987

Electroencephalographic and behavioral studies on the symptoms of the wriggle mouse sagami. Nichidai Igaku Zasshi 47(2): 169-180, 1988

Concentrations of thyrotropin-releasing hormone and substance P in the central nervous system of Wriggle mouse Sagami, a mutant ataxic mouse. Medical Science Research 16(6): 275-276, 1988

New neurological mutant wriggle mouse sagami with an interesting movement disorder. Mouse Genome 90(2): 223-225, 1992

Concentrations of catecholamines and indoleamines in the central nervous system of Wriggle mouse Sagami. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology 93(1): 167-169, 1989

A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami. Biochemical and Biophysical Research Communications 261(3): 773-778, 1999

A poin mutation in a plasma membrane Ca2+-ATPase gene causes deafness in Wriggle Mouse Sagami. Molecular Biology of the Cell 11(Supplement): 223a, 2000