+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Evoked cardiac response components in cognitive processing: differential effects of amyotrophic lateral sclerosis

Evoked cardiac response components in cognitive processing: differential effects of amyotrophic lateral sclerosis

Acta Neurobiologiae Experimentalis 59(4): 329-334

We investigated the mechanism of two evoked cardiac response components associated with different aspects of information processing. Innocuous stimuli presented in an irrelevant condition elicit a simple cardiac deceleration termed ECR1. The same stimuli presented in a relevant condition (such as results from requesting subjects to silently count the stimuli) elicit a complex biphasic response with a large secondary acceleration in heart rate. This difference is attributed to the additional effect of cognitive task performance, resulting in an addition response component, ECR2. This may be realised by subtraction of the two responses. We investigated the mechanisms involved by comparing cardiac response profiles from a neurologically-impaired group with those from a control group amyotrophic lateral sclerosis (ALS) has been associated with a loss of synaptic connections in the frontal lobe. Twelve ALS clinically non-demented patients were age-matched with twelve neurological patients without pathological changes in the brain. Cardiac response profiles for ECR1 and ECR2 were examined as a function of group. ECR1 did not differ between the groups, but ECR2 was significantly impaired in the ALS patients. The results are discussed in terms of different brain regions associated with these two cardiac response components. ECR1 may be associated with automatic preattentive stimulus registration involving, in the case of auditory stimuli, the auditory analyser and associated pathways, while ECR2 appears to be a correlate of controlled executive processing, involving the frontal cortex.

(PDF emailed within 1 workday: $29.90)

Accession: 046024746

Download citation: RISBibTeXText

PMID: 10645638

Related references

Evoked cardiac response as a correlate of cognitive processing in the case of amyotrophic lateral sclerosis. International Journal of Psychophysiology 25(1): 33, 1997

Alteration of early components of the visual evoked potential in amyotrophic lateral sclerosis. Journal of Neurology 245(4): 206-210, 1998

Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration 17(1-2): 69-76, 2016

Cognitive processing in completely paralyzed patients with amyotrophic lateral sclerosis. European Journal of Neurology 10(5): 551-558, September, 2003

Somatosensory evoked potentials in the differential diagnosis between spinal cord compression and amyotrophic lateral sclerosis. Acta Neurologica Scandinavica 92(1): 72-76, 1995

Differential diagnostic criteria of lateral amyotrophic sclerosis and lateral amyotrophic sclerosis syndrome. Zhurnal Nevrologii i Psikhiatrii Imeni S S Korsakova 102(1): 22-25, 2002

Motor evoked potentials (MEPs): evaluation of the different types of responses in amyotrophic lateral sclerosis and primary lateral sclerosis. Electromyography and Clinical Neurophysiology 36(6): 361-368, 1996

Cognitive processing effects on auditory event-related potentials and the evoked cardiac response. International Journal of Psychophysiology 78(2): 100-106, 2011

Somatosensory evoked potentials in amyotrophic lateral sclerosis and primary lateral sclerosis. Revue Neurologique 150(4): 292-298, 1994

Imaging findings associated with cognitive performance in primary lateral sclerosis and amyotrophic lateral sclerosis. Dementia and Geriatric Cognitive Disorders Extra 3(1): 233-250, 2013

Auditory brainstem evoked response (ABSR) of Parkinson-dementia complex and amyotrophic lateral sclerosis in Guam and Japan. Rinsho Shinkeigaku 21(1): 37-41, 1981

Characterization of Ca(2+)-channels responsible for K(+)-evoked [(3)H]noradrenaline release from rat brain cortex synaptosomes and their response to amyotrophic lateral sclerosis IgGs. Experimental Neurology 159(2): 520-527, 1999

Dissociation of the thresholds of excitatory and inhibitory effects evoked by magnetic cortical stimulation in amyotrophic lateral sclerosis. Society for Neuroscience Abstracts 20(1-2): 620, 1994

Differential expression of microRNA-206 in the gastrocnemius and biceps brachii in response to CSF from sporadic amyotrophic lateral sclerosis patients. Journal of the Neurological Sciences 345(1-2): 254-256, 2015