Fatal group A Streptococcal toxic shock-like syndrome in a child with varicella: report of the first well documented case with detection of the genetic sequences that code for exotoxins spe A and B, in São Paulo, Brazil

Sztajnbok, J.; Lovgren, M.; Brandileone, M.C.; Marotto, P.C.; Talbot, J.A.; Seguro, A.C.

Revista do Instituto de Medicina Tropical de Sao Paulo 41(1): 63-65


ISSN/ISBN: 0036-4665
PMID: 10436672
Accession: 046078940

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A previously healthy seven-year-old boy was admitted to the intensive care unit because of toxaemia associated with varicella. He rapidly developed shock and multisystem organ failure associated with the appearance of a deep-seated soft tissue infection and, despite aggressive treatment, died on hospital day 4. An M-non-typable, spe A and spe B positive Group A Streptococcus was cultured from a deep soft tissue aspirate. The criteria for defining Streptococcal toxic shock-like syndrome were fulfilled. The authors discuss the clinical and pathophysiological aspects of this disease as well as some unusual clinical findings related to this case.