+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Gastric emptying characteristics of a novel (13)C-octanoate-labeled muffin meal



Gastric emptying characteristics of a novel (13)C-octanoate-labeled muffin meal



Journal of Clinical Gastroenterology 32(5): 394-399



Determine the gastric emptying characteristics of a novel, 350-kcal test meal consisting of two muffins, using scintigraphy and the 13C-octanoate breath test (OBT). Healthy volunteers underwent three studies on separate days within a 1-week period. On day 1, we measured emptying of the 350-kcal muffin test meal labeled simultaneously with 99mTc sulfur colloid and 13C-octanoate. On day 2, reproducibility of the OBT using a single-labeled 350-kcal test meal was assessed. On day 3, the effect of erythromycin on the 350-kcal OBT was determined. The mean (+/-SD) half-emptying time (T1/2) as measured by scintigraphy was 104 +/- 24 minutes, versus 212 +/- 52 minutes by OBT. There was a strong correlation between T1/2 determined by scintigraphy and the breath test (r = 0.83). Multiple linear regression analysis identified a significant relationship between T1/2 determined by scintigraphy and the 90-and 180-minute breath samples. There was a strong correlation (r = 0.830, slope = 0.732 +/- 0.120 [SE], intercept = 26.4 +/- 12.7) between the T1/2 obtained using the regression equation and the actual T1/2 obtained by scintigraphy. The mean T1/2 (+/-SD) for replicate determinations using the OBT was 209 +/- 52 minutes, compared with 196 +/- 42 minutes on days 1 and 2, respectively (not significant, p = 0.28, paired Student t test). Treatment with erythromycin on day 3 produced a significant decrease in T1/2 (155 +/- 49 minutes, p = 0.002). The 350-kcal muffin meal OBT provides a convenient, nonscintigraphic way of measuring solid-phase gastric emptying. Multiple linear regression appears promising as a method of analyzing OBT data and may allow for an abbreviated breath test protocol.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 046148728

Download citation: RISBibTeXText

PMID: 11319309

DOI: 10.1097/00004836-200105000-00007


Related references

Gastric emptying characteristics of a novel muffin meal Comparison of 13C-octanoate breath testing and scintigraphy. Gastroenterology 116(4 Part 2): A971, 1999

Effect of meal size and test duration on gastric emptying as determined by breath test in normal subjects using a muffin meal labeled with 13C-sodium octanoate. Gastroenterology 118(4 Suppl 2 Part 1): AGA A143, 2000

Effect of meal size and test duration on gastric emptying and gastric myoelectrical activity as determined with simultaneous [13C]octanoate breath test and electrogastrography in normal subjects using a muffin meal. Digestive Diseases and Sciences 46(12): 2643-2650, 2001

Measurement of solid phase gastric emptying with a simplified muffin meal using breath testing with either 13C-octanoate or 13C-acetate. Gastroenterology 120(5 Suppl. 1): A 466, 2001

Simultaneous measurement of gastric emptying with a simple muffin meal using octanoate breath test and scintigraphy in normal subjects and patients with dyspeptic symptoms. Digestive Diseases and Sciences 47(7): 1657-1663, 2002

Impaired gastric emptying of a solid test meal in patients with Parkinson's disease using 13C-sodium octanoate breath test. Neuroscience Letters 375(3): 170-173, 2005

Gastric emptying of a radionuclide-labeled test meal after surgical correction of gastric dilatation-volvulus in dogs. American Journal of Veterinary Research 50(3): 433-435, 1989

Gastric emptying time (GET) with Tc-99m-labeled semisolid meal in diabetic patients. Kaku Igaku. Japanese Journal of Nuclear Medicine 21(1): 19-26, 1984

Measurement of gastric emptying in infants with technetium 99m labeled solid phase meal. Pediatric Research 14(4 Part 2): 495, 1980

Gastric emptying of radionuclide-labeled solid meal in beagle dogs using a scintigraphic method. Methods and Findings in Experimental and Clinical Pharmacology 15(7): 459-463, 1993

Gastric emptying time with technetium 99m labeled semi solid meal in diabetic patients. Kaku Igaku 21(1): 19-26, 1984

Gastric emptying in infants with gastroesophageal reflux. Measurement with a technetium-99m-labeled semisolid meal. Digestive Diseases and Sciences 33(4): 393-399, 1988

Half-time (1/2 T) of gastric emptying after a physiological meal labeled with 99m-Tc A1b in dyspeptic patients before and after metoclopramide administration. Bollettino Della Societa Italiana di Biologia Sperimentale 53(10): 771-775, 1977

Effect of calcitonin on gastric emptying after isotope-labeled solid meal in patients with stomach ulcer. Polskie Archiwum Medycyny Wewnetrznej 84(6): 357-362, 1990

Technetium 99m labeled solid phase meal a quantitative clinical measurement of human gastric emptying. Clinical Research 26(6): 793A, 1978