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Halonal is a phenobarbital inductor of the monooxygenase system



Halonal is a phenobarbital inductor of the monooxygenase system



Bulletin of Experimental Biology and Medicine 134(3): 264-266



Experiments on rats demonstrated induction of the hepatic monooxygenase system with halonal. The effects of halonal and phenobarbital on the contents of cytochrome P-450 and its isoform P-450b+e and on the rate of substrate metabolism were similar. This suggests that enzyme-inducing activity of halonal is determined by the effect of its major metabolite. It cannot be excluded that halonal molecules possess intrinsic enzyme-inducing activity.

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Accession: 046210288

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PMID: 12511998


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