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Haloperidol induces changes in the electrocorticogram of rats with genetic petit mal epilepsy



Haloperidol induces changes in the electrocorticogram of rats with genetic petit mal epilepsy



Zhurnal Vysshei Nervnoi Deiatelnosti Imeni i P Pavlova 48(6): 1111-1114



The WAG/Rij rats, a genetic animal model of human absence epilepsy, were injected with D2 autoreceptor antagonist haloperidol. Increase in the amount of spike-wave discharges and the prevalence of short spike-wave discharges was observed. The pattern of spike-wave discharge sequence changed in a characteristic way. The findings may testify to participation of dopaminergic system both in the processes of generation and cessation of the spike-wave complex absence epilepsy.

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Accession: 046210329

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PMID: 9929923


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