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Haloperidol-induced catalepsy is influenced by adenosine receptor antagonists



Haloperidol-induced catalepsy is influenced by adenosine receptor antagonists



Polish Journal of Pharmacology 49(5): 323-327



Cataleptogenic effects of haloperidol (1 mg/kg i.p.) in rats was antagonized by caffeine and theophylline (10-50 mg/kg i.p.), and by selective adenosine A2 receptor antagonist (3,7-dimethyl-1-propargylxanthine) (3 and 6 mg/kg i.p.). Selective A1-adenosine receptor antagonist (8-cyclopentyltheophylline) (1.5 and 3 mg/kg i.p.) was not able to reduce this effect of haloperidol. These results confirm the antagonistic interaction between adenosine A2A and dopamine D2 receptors, and suggest the involvement of adenosine A2 receptors in the mechanisms of catalepsy.

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Accession: 046210356

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PMID: 9566031


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